{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:30:00Z","timestamp":1760401800906,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Preclinical Research<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n\n<\/jats:table-wrap><\/jats:p><jats:p>Frontotemporal lobar degeneration (<jats:styled-content style=\"fixed-case\">FTLD<\/jats:styled-content>) encompasses a spectrum of neurodegenerative disorders characterized by behavioral, executive and language impairment, with a common overlap with parkinsonism and motor\u2010neuron disease. Despite an increased understanding of its genetic background and molecular pathophysiology, <jats:styled-content style=\"fixed-case\">FTLD<\/jats:styled-content> is still an orphan disorder and there are currently no effective therapies available. In this brief overview we report the results obtained by several high\u2010throughput and bioinformatic studies aimed at discovering impairment in the transcriptional profiles in brain and peripheral tissues from <jats:styled-content style=\"fixed-case\">FTLD<\/jats:styled-content> patients and in animal models. Taken together, all these results provide an interesting but still fragmentary list of genes and <jats:styled-content style=\"fixed-case\">miRNAs<\/jats:styled-content> whose role in <jats:styled-content style=\"fixed-case\">FTLD<\/jats:styled-content> should be thoroughly investigated.<\/jats:p>","DOI":"10.1002\/ddr.21224","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T19:38:30Z","timestamp":1409859510000},"page":"366-371","source":"Crossref","is-referenced-by-count":3,"title":["Microarray Gene and <scp>miRNA<\/scp> Expression Studies: Looking for New Therapeutic Targets for Frontotemporal Lobar Degeneration"],"prefix":"10.1002","volume":"75","author":[{"given":"Elena","family":"Milanesi","sequence":"first","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Department of 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