{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:26:37Z","timestamp":1760401597840,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n<jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Preclinical Research<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n<\/jats:table-wrap><\/jats:p><jats:p><jats:italic>Krameria cytisoides<\/jats:italic> is used for the treatment of inflammation, stomach pain, and gastric ulcers. The active ingredient from this plant is a peroxide, kramecyne (KACY) which has anti\u2010inflammatory effects. The aim of the present study was to evaluate the anti\u2010inflammatory activities of KACY in lipopolysaccharide (LPS)\u2010induced systemic chronic inflammation in mice for 60 days, using dexamethasone (DEX) as the positive control, vehicle (the LPS group) as the negative control and the control group (mice without inflammation). KACY did not affect survival, body weight or relative organ weight in mice but it: decreased nitric oxide (NO) production by 68%; prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) by 67%; increased release of anti\u2010inflammatory cytokine IL\u201010 (2.0\u2010fold), and reduced production of the proinflammatory cytokines, IL\u20106 (2.0\u2010fold), IL\u20101\u03b2 (2.4\u2010fold), and TNF\u2010\u03b1 (2.0\u2010fold). Furthermore, the gastroprotective effects of KACY in mice were evaluated in an ethanol\u2010induced gastric ulcer model. The results showed that KACY at 50 and 100 mg\/kg exerted gastroprotective effects with similar activity to 50 mg\/kg ranitidine. In gastric tissues, KACY decreased the level of malondialdehyde (MDA) but increased the catalase (CAT) activity. KACY have potential for the treatment of chronic inflammatory diseases due its similar activity to that of DEX. It also has gastroprotective effects. Drug Dev Res 76 : 185\u2013193, 2015.  \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ddr.21254","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T02:48:38Z","timestamp":1435200518000},"page":"185-193","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Kramecyne on <scp>LPS<\/scp> Induced Chronic Inflammation and Gastric Ulcers"],"prefix":"10.1002","volume":"76","author":[{"given":"Angel Josabad","family":"Alonso\u2010Castro","sequence":"first","affiliation":[{"name":"Departamento de Sistemas Biol\u00f3gicos Universidad Aut\u00f3noma Metropolitana unidad Xochimilco Calzada del Hueso 1100, Col. 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