{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:37:11Z","timestamp":1779385031814,"version":"3.53.1"},"reference-count":283,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,21]],"date-time":"2016-02-21T00:00:00Z","timestamp":1456012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n<jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Preclinical Research<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n<\/jats:table-wrap><\/jats:p><jats:p>In this review, we discuss epigenetic\u2010driven methods for treating neurodegenerative disorders associated with mitochondrial dysfunction, focusing on carnitinoid antioxidant\u2010histone deacetylase inhibitors that show an ability to reinvigorate synaptic plasticity and protect against neuromotor decline in vivo. Aging remains a major risk factor in patients who progress to dementia, a clinical syndrome typified by decreased mental capacity, including impairments in memory, language skills, and executive function. Energy metabolism and mitochondrial dysfunction are viewed as determinants in the aging process that may afford therapeutic targets for a host of disease conditions, the brain being primary in such thinking. Mitochondrial dysfunction is a core feature in the pathophysiology of both Alzheimer and Parkinson diseases and rare mitochondrial diseases. The potential of new therapies in this area extends to glaucoma and other ophthalmic disorders, migraine, Creutzfeldt\u2013Jakob disease, post\u2010traumatic stress disorder, systemic exertion intolerance disease, and chemotherapy\u2010induced cognitive impairment. An emerging and hopefully more promising approach to addressing these hard\u2010to\u2010treat diseases leverages their sensitivity to activation of master regulators of antioxidant and cytoprotective genes, antioxidant response elements, and mitophagy. Drug Dev Res 77 : 109\u2010123, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ddr.21294","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:42:52Z","timestamp":1456101772000},"page":"109-123","source":"Crossref","is-referenced-by-count":47,"title":["Epigenetic Treatment of Neurodegenerative Disorders: Alzheimer and Parkinson Diseases"],"prefix":"10.1002","volume":"77","author":[{"given":"Michael H.","family":"Irwin","sequence":"first","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter H.","family":"Moos","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, School of Pharmacy University of California San Francisco San Francisco CA USA"},{"name":"SRI Biosciences, A Division of SRI International Menlo Park CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas V.","family":"Faller","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Boston University School of Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosta","family":"Steliou","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Boston University School of Medicine Boston MA USA"},{"name":"PhenoMatriX, Inc. 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