{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:44:47Z","timestamp":1791233087376,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Key Technology R&D Program","award":["2011BAI13B02-1),"],"award-info":[{"award-number":["2011BAI13B02-1),"]}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"crossref","award":["20130182110023"],"award-info":[{"award-number":["20130182110023"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"name":"High-end Engineering and Technical Personnel Training Plan of Chongqing"},{"name":"County-University cooperation Innovation Funds of Southwest University","award":["SZ201501, Sz201401, Sz201302"],"award-info":[{"award-number":["SZ201501, Sz201401, Sz201302"]}]},{"name":"The Major Program of Chongqing Educational Commission","award":["KJZH14203"],"award-info":[{"award-number":["KJZH14203"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n<jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Preclinical Research<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n<\/jats:table-wrap><\/jats:p><jats:p><jats:italic>Rhizoma Coptidis<\/jats:italic> (RC), the root of <jats:italic>Coptis chinensis Franch<\/jats:italic>, a species in the genus <jats:italic>Coptis<\/jats:italic> (family <jats:italic>Ranunculaceae<\/jats:italic>), has been commonly prescribed for the treatment of diabetes in Chinese traditional herbal medicine applications. The present study is focused on the assessment of the antihyperglycemia and antidiabetic hyperlipidemia effect of five protoberberine alkaloids, berberine (BBR), coptisine (COP), palmatine (PAL), epiberberine (EPI), and jatrorrhizine (JAT), separated from <jats:italic>R. Coptidis<\/jats:italic> in hepatocellular carcinoma HepG2 cells and diabetic KK\u2010Ay mice. Protoberberine alkaloids are effective in modulating hyperglycemia and hyperlipidemia. After adding BBR and COP to culture medium, glucose consumption of HepG2 cells was increased. In KK\u2010Ay mice assays, suppressed fasting blood glucose level and ameliorated glucose tolerance were observed after BBR\/COP administration. After treated with berberine and coptisine, in the same dose of 5 \u00b5g\/mL, the glucose consumption of HepG2 cells were promoted and, respectively, reached 96.1% and 17.6%. Body weight, food consumption, water intake, and urinary output of KK\u2010Ay mice were reduced after treated with EPI. Serum total cholesterol and triglyceride of mice were decreased after treated with palmatine and jatrorrhizine. Serum high\u2010density lipoprotein cholesterol of mice was increased after palmatine, jatrorrhizine, and berberine administrated. Moreover, hepatomegaly was attenuated in JTR\u2010treated mice. Suggested that these protoberberine alkaloids from <jats:italic>R. Coptidis<\/jats:italic> have potential curative effect for diabetes. Drug Dev Res 77 : 163\u2013170, 2016. \u2003\u2003\u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ddr.21302","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T03:30:32Z","timestamp":1459740632000},"page":"163-170","source":"Crossref","is-referenced-by-count":54,"title":["Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK\u2010Ay Mice"],"prefix":"10.1002","volume":"77","author":[{"given":"Hang","family":"Ma","sequence":"first","affiliation":[{"name":"School of Pharmacy Southwest University Chongqing 400716 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinran","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Southwest University Chongqing 400716 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyao","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Southwest University Chongqing 400716 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Feng","sequence":"additional","affiliation":[{"name":"Chongqing Technology and Business University Chongqing 400067 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Life Science Southwest University Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Southwest University Chongqing 400716 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.11.045"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.12.6.647"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/o90-136"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800059-JLR200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.09.014"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"26","article-title":"Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol\u2010lowering agents\u2014a single\u2010blind clinical investigation","volume":"57","author":"Cicero AEG","year":"2007","journal-title":"Arzneimittelforschung"},{"issue":"4","key":"e_1_2_6_8_1","first-page":"353","article-title":"Effects of chronic ramipril treatment in streptozotocin\u2010induced diabetic rats","volume":"41","author":"Hakim ZS","year":"1997","journal-title":"Indian J Physiol Pharmacol"},{"key":"e_1_2_6_9_1","unstructured":"International Diabetes Federation (IDF).2015. 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