{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:25:13Z","timestamp":1782516313412,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,9,17]],"date-time":"2017-09-17T00:00:00Z","timestamp":1505606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n<jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Preclinical Research<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n<\/jats:table-wrap><\/jats:p><jats:p>The effects of methyl jasmonate (MJ; 5, 10, 20 mg\/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)\u2010induced depression\u2010like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg\/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed. MJ decreased immobility time in the TST and reversed impaired intake of sucrose relative to the stressed control suggesting antidepressant\u2010like activity. MJ also reduced UCMS\u2010induced increases in corticosterone and MDA (malondialdehyde) levels and attenuated UCMS\u2010induced decreases in GSH and TNF\u2010\u03b1 levels and SOD activity. These findings suggest that MJ attenuated UCMS\u2010induced depressive\u2010like behaviors through decreased levels of corticosterone and decreasing oxidative stress and neuroinflammation in mouse brain.Drug Dev Res 78 : 381\u2010389, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ddr.21410","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T10:23:55Z","timestamp":1505730235000},"page":"381-389","source":"Crossref","is-referenced-by-count":8,"title":["Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress\u2010Induced Behavioral and Biochemical Alterations in Mouse Brain"],"prefix":"10.1002","volume":"78","author":[{"given":"Adaeze","family":"Adebesin","sequence":"first","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of medicine University of Ibadan Ibadan 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