{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T19:50:55Z","timestamp":1778269855593,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,9,17]],"date-time":"2017-09-17T00:00:00Z","timestamp":1505606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"publisher","award":["2016A030313259"],"award-info":[{"award-number":["2016A030313259"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"publisher","award":["2015A030310451"],"award-info":[{"award-number":["2015A030310451"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n<jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Preclinical Research<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n<\/jats:table-wrap><\/jats:p><jats:p>Osteoarthritis (OA) is a widely prevalent degenerative joint disease that severely impairs the health of the elderly population resulting in a heavy economic burden worldwide. Coenzyme Q10 (CoQ10) has shown anti\u2010inflammatory effects in some diseases. The present study aimed to investigate if CoQ10 would suppress catabolic responses of interleukin (IL)\u20101\u03b2\u2010induced chondrocytes. Rat chondrocytes were cultured and pretreated with CoQ10, and then stimulated with or without IL\u20101\u03b2 (10 ng\/ml). The expression and production of matrix metalloproteinase (MMP)\u20103, MMP\u20109, and MMP13 were determined using real\u2010time PCR and Western blotting. CoQ10 suppressed MMP\u20103, MMP\u20109, and MMP13 production induced by IL\u20101\u03b2, and markedly inhibited IL\u20101\u03b2\u2010induced MAPK pathways in rat chondrocytes. The present study provides insight into potential mechanisms by which CoQ10 protects against degeneration of cartilage in patients with OA, which may lead to new approaches for the treatment of OA.Drug Dev Res 78 : 403\u2010410, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ddr.21412","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T10:23:47Z","timestamp":1505730227000},"page":"403-410","source":"Crossref","is-referenced-by-count":25,"title":["Coenzyme Q10 Prevents the Interleukin\u20101 Beta Induced Inflammatory Response via Inhibition of MAPK Signaling Pathways in Rat Articular Chondrocytes"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-8962","authenticated-orcid":false,"given":"Xing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Joint Surgery The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 510080 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