{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T10:49:55Z","timestamp":1772880595551,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JGR-G","award":["SIP 20150714"],"award-info":[{"award-number":["SIP 20150714"]}]},{"name":"HIR-G","award":["SIP 20150714"],"award-info":[{"award-number":["SIP 20150714"]}]},{"name":"Laboratorios Medix S.A. de C.V."}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n<jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Preclinical Research &amp; Development<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n<\/jats:table-wrap><\/jats:p><jats:p>Current drugs for obesity treatment have limited efficacy and considerable adverse effects. Combination of drugs with complementary mechanisms of action at lower doses may produce a greater efficacy with a better safety profile. This study was designed to assess the anorectic effect and safety of a diethylpropion\u2009+\u2009topiramate mixture in rats. The anorectic effect of drugs was measured using a sweetened milk consumption model, and the corresponding interaction was determined by isobolographic analysis, interaction index and confidence intervals. Additionally, blood pressure was measured using a sphygmomanometer in the rat tail. Diethylpropion and topiramate alone or in combination increased the anorectic effect in a dose\u2010dependent fashion in either nondeprived or 12 hr food\u2010deprived rats. All theoretical ED<jats:sub>30<\/jats:sub> values of diethylpropion\u2009+\u2009topiramate combinations at 1:1, 1:3, and 3:1 dose ratios were significantly higher than experimental ED<jats:sub>30<\/jats:sub> values. In addition, interaction indices and confidence intervals confirmed the potentiation between both drugs. Theoretical ED<jats:sub>30<\/jats:sub> of diethylpropion\u2009+\u2009topiramate combination did not affect the blood pressure. Data suggests that low doses of the diethylpropion\u2009+\u2009topiramate combination can potentiate the anorectic effect of individual drugs with a better safety profile, which deserves further investigation in clinical trials.<\/jats:p>","DOI":"10.1002\/ddr.21434","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T11:16:25Z","timestamp":1536232585000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anorectic efficacy and safety of the diethylpropion\u2010topiramate combination in rats"],"prefix":"10.1002","volume":"79","author":[{"given":"Gabriela Y.","family":"Cort\u00e9s\u2010Moreno","sequence":"first","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional. Plan de San Luis y D\u00edaz Mir\u00f3n s\/n, Col. 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