{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:18:40Z","timestamp":1770232720012,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study different derivatives of ferrocene\u2010incorporated acyl ureas and homoleptic cadmium carboxylates were investigated for potential anticonvulsant, anxiolytic and sedative properties, using in\u2010silico and in\u2010vivo techniques. The molecular docking studies reveled that ferrocene compounds derivative 1\u2010(4\u2010bromobenzoyl)\u20103\u2010(4\u2010ferrocenylphenyl) urea (PB1) and cadmium compounds derivative bis (diphenylacetato) cadmium (II) (DPAA) exhibit binding affinities against various neurotherapeutic molecular targets involved in epilepsy, anxiety, and sedation. Both PB1 and DPAA showed high binding affinities against protein targets like mammalian shaker voltage dependent potassium channel beta subunit complex, calcium release\u2010activated calcium channel, sodium channel 2A inactivation gate, human sodium\/hydrogen exchanger regulatory factor, and gamma amino butyric acid A receptor associated protein. PB1 (2\u201310 mg\/kg) and DPAA (1\u20135 mg\/kg) delayed onset time of pentylenetetrazole\u2010induced myoclonic jerks and tonic\u2010clonic seizures in mice while decreased duration of tonic\u2010clonic seizures, determining the anticonvulsant effect of these compounds. PB1 and DPAA (0.5\u20131 mg\/kg) exhibited anxiolytic effect by increasing time spent and number of animals entries into open arms, while decreasing time spent in dark compartment. Furthermore, PB1 (0.5\u20131 mg\/kg) and DPAA (0.1\u20131 mg\/kg) reduced onset time of sleep and increased duration time of sleep in mice, showing sedative effect. Taken together, our results indicate that aforementioned derivatives of ferrocene and cadmium are potent neurotherapeutic agents possessing anticonvulsant, anxiolytic and sedative properties.<\/jats:p>","DOI":"10.1002\/ddr.21435","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T07:31:57Z","timestamp":1531207917000},"page":"184-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["In silico and in vivo investigation of ferrocene\u2010incorporated acyl ureas and homoleptic cadmium carboxylate derivatives for anticonvulsant, anxiolytic, and sedative potential"],"prefix":"10.1002","volume":"79","author":[{"given":"Sadia","family":"Adil","sequence":"first","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences, Riphah International University Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-0414","authenticated-orcid":false,"given":"Arif\u2010ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences, Riphah International University Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroon","family":"Badshah","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences, Riphah International University Islamabad Pakistan"},{"name":"Department of Pharmacy Abdul Wali Khan University Mardan Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiza","family":"Asghar","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Wah Wah  Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Usman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Quaid e Azam University Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Badshah","sequence":"additional","affiliation":[{"name":"Department of Chemistry Quaid e Azam University Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saqib","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Chemistry Quaid e Azam University Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(88)90046-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2015.10.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2015.08.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.01001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.561"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"85","article-title":"Procedural sedation in the acute care setting","volume":"71","author":"Brown T. 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