{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:24:05Z","timestamp":1779189845135,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T00:00:00Z","timestamp":1538784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"College of Medicine & Health Sciences, United Arab Emirates University","award":["NP-14-14"],"award-info":[{"award-number":["NP-14-14"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal ischemia\u2013reperfusion injury (IRI) induces the production of aldehydes which are detoxified by aldehyde dehydrogenases (ALDHs). Alda\u20101 is a selective ALDH2 agonist and its protective effect was demonstrated in several conditions. The effect of Alda\u20101 on the kidney or on renal IRI was not investigated. We investigated the effect of Alda\u20101 on the renal dysfunction following IRI. Wistar rats underwent left IRI for 40\u2009min. Group\u2010Alda (<jats:italic>n<\/jats:italic>\u2009=\u200911) received Alda\u20101 starting 24\u2009h before IRI and continued for 7 days thereafter when renal functions were measured. Group\u2010Vx (<jats:italic>n<\/jats:italic>\u2009=\u200911) underwent similar protocol but received the dissolvent. Alda\u20101 did not affect renal blood flow or glomerular filtration rate in the left ischemic kidney in Group\u2010Alda compared to Group\u2010Vx (3.05\u2009\u00b1\u20090.50 vs. 3.53\u2009\u00b1\u20090.70, and 0.40\u2009\u00b1\u20090.06 vs. 0.51\u2009\u00b1\u20090.08, respectively, <jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05 for both). However, left renal fractional sodium excretion was higher in Group\u2010Alda (2.80\u2009\u00b1\u20090.43 vs. 1.37\u2009\u00b1\u20090.36, <jats:italic>p<\/jats:italic>\u2009=\u2009.02). Alda\u20101 also adversely affected the gene expressions of kidney injury molecule\u20101 and neutrophil gelatinase\u2010associated lipocalin (217\u2009\u00b1\u200938 vs. 99\u2009\u00b1\u200913 and 49\u2009\u00b1\u200913 vs. 20\u2009\u00b1\u20095, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05 for both) and the alterations in tumor necrosis factor\u2010\u03b1, transforming growth factor\u2010\u03b21, plasminogen activator inhibitor\u20101, fibronectin 1 and p53 (4.4\u2009\u00b1\u20090.9 vs. 2.1\u2009\u00b1\u20090.3, 1.5\u2009\u00b1\u20090.1 vs. 1.1\u2009\u00b1\u20090.1, 30.0\u2009\u00b1\u20092.7 vs. 11.7\u2009\u00b1\u20092.3, 3.6\u2009\u00b1\u20090.4 vs. 2.1\u2009\u00b1\u20090.2 and 1.3\u2009\u00b1\u20090.1 vs. 0.9\u2009\u00b1\u20090.07, respectively, <jats:italic>p<\/jats:italic>\u2009\u2264\u2009.05 for all). This was associated with intratubular crystal deposition suggestive of crystalline nephropathy. Alda\u20101 exacerbated the IRI\u2010induced renal tubular dysfunction and alterations in markers of acute kidney injury, biomarkers of inflammation, fibrosis and apoptosis and this was associated with intratubular crystal deposition suggestive of crystalline nephropathy.<\/jats:p>","DOI":"10.1002\/ddr.21454","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T11:04:28Z","timestamp":1538823868000},"page":"315-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Alda\u20101, an aldehyde dehydrogenase\u20102 agonist, causes deterioration in renal functions following ischemia\u2013reperfusion injury due to crystalline nephropathy"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-0863","authenticated-orcid":false,"given":"Fayez T.","family":"Hammad","sequence":"first","affiliation":[{"name":"Department of Surgery and College of Medicine and Health Sciences United Arab Emirates University  Al Ain United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail","family":"Al\u2010Salam","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine and Health Sciences United Arab Emirates University  Al Ain United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Yuvaraju","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences United Arab Emirates University  Al Ain United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loay","family":"Lubbad","sequence":"additional","affiliation":[{"name":"Department of Surgery and College of Medicine and Health Sciences United Arab Emirates University  Al Ain United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.37.5.558"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.10.030"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1158554"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.09.016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30522-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001563"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68626-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027276"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.10.140"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu125"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.69"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932376"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932485"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"70","article-title":"The effect of aliskiren on the renal dysfunction following unilateral ureteral obstruction in the rat","volume":"8","author":"Hammad F. 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