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Snake venoms are natural catalogs of multifunctional toxins and privileged frameworks, which serve as potential templates for the inspiration of novel treatment strategies for combating antibiotic resistant bacteria. Phospholipases A<jats:sub>2<\/jats:sub> (PLA<jats:sub>2<\/jats:sub>s) are one of the main classes of antibacterial biomolecules, with recognized therapeutic value, found in these valuable secretions. Recently, a number of biomimetic oligopeptides based on small fragments of primary structure from PLA<jats:sub>2<\/jats:sub> toxins has emerged as a meaningful opportunity to overcome multidrug\u2010resistant clinical isolates. Thus, this review will highlight the biochemical and structural properties of antibacterial PLA<jats:sub>2<\/jats:sub>s and peptides thereof, as well as their possible molecular mechanisms of action and key roles in development of effective therapeutic strategies. 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