{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:45:10Z","timestamp":1773197110119,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T00:00:00Z","timestamp":1537660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006054","name":"Universidad de Guanajuato","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Soulattrolide is a natural coumarin synthesized by the leaves of species of <jats:italic>Calophyllum<\/jats:italic> (Calophyllaceae) rain forest trees, including the American <jats:italic>C. brasiliense<\/jats:italic>, and the Asian <jats:italic>C. teysmanii<\/jats:italic>. Soulattrolide is a potent inhibitor of the reverse transcriptase from HIV\u20101 (RT\u2010HIV\u20101), and active against <jats:italic>Mycobacterium tuberculosis<\/jats:italic>. However, the effects of this coumarins on other systems, remains to be evaluated. <jats:styled-content style=\"fixed-case\"><jats:italic>C. brasiliense<\/jats:italic><\/jats:styled-content> is used in traditional medicine for the treatment of pain and inflammation. Therefore, we decided to explore the antinociceptive, anti\u2010inflammatory activity of soulattrolide in mice, as well as, some of its possible effects on the CNS. Soulattrolide showed antinociceptive effects in the writhing test (ED<jats:sub>50<\/jats:sub>\u2009=\u200933.8 mg\/kg), as well as, in the formalin test with an ED<jats:sub>50<\/jats:sub>\u2009=\u20097.9, and 22.1 mg\/kg for Phases 1 and 2, respectively. The highest dose of soulattrolide (50\u2009mg\/kg) induced 40% of antinociception in the hot plate test. Regarding to anti\u2010inflammatory activity, in the 12\u2010O\u2010Tetradecanoylphorbol\u201013\u2010acetate (TPA) test, soulattrolide showed an IC<jats:sub>50<\/jats:sub>\u2009=\u20091.81\u2009\u03bcmol\/ear, whereas in the myeloperoxidase assay, it showed an inhibition of 87% (1 \u03bcmol\/ear). Soulattrolide showed sedative effects on the pentobarbital\u2010induced sleeping time test, and the rotarod test, but lacked antidepressant activity on the tail suspension test. In conclusion, we report for the first time, the antinociceptive effects of soulattrolide in mice, like those of naproxen; soulattrolide also showed mild anti\u2010inflammatory activity, as well as mild sedative and anxiolytic properties, therefore, it has also activity on the CNS.<\/jats:p>","DOI":"10.1002\/ddr.21471","type":"journal-article","created":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T10:08:26Z","timestamp":1537697306000},"page":"332-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antinociceptive, anti\u2010inflammatory, and central nervous system (CNS) effects of the natural coumarin soulattrolide"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-8156","authenticated-orcid":false,"given":"Angel Josabad","family":"Alonso\u2010Castro","sequence":"first","affiliation":[{"name":"Departamento de Farmacia, Divisi\u00f3n de Ciencias Naturales y Exactas Universidad de Guanajuato  Guanajuato Guanajuato Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Laura","family":"Guzm\u00e1n\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Catedr\u00e1tica CONACyT\u2010Instituto de Investigaciones Biom\u00e9dicas Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara Alba","family":"Betancourt","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Divisi\u00f3n de Ciencias Naturales y Exactas Universidad de Guanajuato  Guanajuato Guanajuato Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deisy","family":"Gasca\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto de Neurobiolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico  Juriquilla Quer\u00e9taro Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Lorena","family":"\u00c1lvarez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Divisi\u00f3n de Ciencias Naturales y Exactas Universidad de Guanajuato  Guanajuato Guanajuato Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"P\u00e9rez\u2010Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Departamento de Productos Naturales Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara In\u00e9s","family":"Espitia\u2010Pinz\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas, Departamento de Inmunolog\u00eda Universidad Nacional Aut\u00f3noma  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Reyes\u2010Chilpa","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Departamento de Productos Naturales Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21397"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.12.041"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0963180115000092"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053507315"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01274-3"},{"issue":"4","key":"e_1_2_7_7_1","first-page":"431","article-title":"Chemical composition and analgesic activity of Calophyllum brasiliense leaves","volume":"56","author":"Da Silva K. L.","year":"2001","journal-title":"Th\u00e9rapie"},{"issue":"2","key":"e_1_2_7_8_1","first-page":"126","article-title":"The tropical tree Calophyllum brasiliense: A botanical, chemical, and pharmacological review","volume":"21","author":"Garc\u00eda\u2010Zebad\u00faa J. C.","year":"2014","journal-title":"Vitae"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12245"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.03.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020334"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1471"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.07.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-017-1366-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-007-9029-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2006.09.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2012.718352"},{"key":"e_1_2_7_18_1","volume-title":"TREAT\u2010NMD neuromuscular network. Experimental protocols for DMD animal models. DMD_ M.2.1.002","author":"Nagaraju K.","year":"2010"},{"key":"e_1_2_7_19_1","unstructured":"Norma Oficial Mexicana (Official Mexican Standard) NOM\u2010062\u2010ZOO\u20101999 Especificaciones t\u00e9cnicas para la producci\u00f3n cuidado y uso de los animales de laboratorio (Technical specifications for the production care and use of laboratory animals) 1999."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.01.018"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960399y"},{"issue":"22","key":"e_1_2_7_22_1","first-page":"2095","article-title":"Sleep\u2010prolonging effect of Coriandrum sativum hydro\u2010alcoholic extract in mice","volume":"26","author":"Rakhshandeh H.","year":"2012","journal-title":"Natural Product Research"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.02.039"},{"issue":"6","key":"e_1_2_7_24_1","first-page":"385","article-title":"Natural compounds of the Clusisaceae family: Type 1 human immunodeficiency virus inhibitors","volume":"34","author":"Reyes\u2010Chilpa R.","year":"2009","journal-title":"Interciencia"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.03.026"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2009-1-210"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.44"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2003.11.012"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddr.21471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:42:23Z","timestamp":1760377343000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,23]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/ddr.21471"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21471","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,23]]},"assertion":[{"value":"2018-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}