{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:16:54Z","timestamp":1791389814416,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T00:00:00Z","timestamp":1540684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EU FP7 KBBE project \u201cMarine Fungi\u201d","award":["265926"],"award-info":[{"award-number":["265926"]}]},{"name":"Ministry of Science, Economic Affairs and Transport of the State of Schleswig-Holstein (Germany) in the frame of the \u201cFuture Program for Economy\u201d, which is co-financed by the European Union"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Natural products and derivatives thereof are of considerable importance in the discovery of new pharmaceuticals, for example, for the treatment of cancer, diabetes, inflammation diseases, and infection diseases caused by bacteria, fungi, viruses, or parasites. The great biodiversity of marine microorganisms is reflected in their huge chemical diversity, which provides a rich source of biologically active compounds. An increasing interest in marine microorganisms as promising producers of new compounds with potential medical applications has raised increasing interest in the sustainable exploration of marine microbial resources for the discovery of new antibiotics, which is highlighted. The bottlenecks in the development of drugs using the large marine natural product pipeline are also discussed.<\/jats:p>","DOI":"10.1002\/ddr.21482","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T01:58:58Z","timestamp":1540778338000},"page":"24-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Marine bacteria and fungi as promising source for new antibiotics"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-5306","authenticated-orcid":false,"given":"Jutta","family":"Wiese","sequence":"first","affiliation":[{"name":"RD3 \u2010 Marine Ecology, RU \u2010 Marine Microbiology GEOMAR Helmholtz Centre for Ocean Research Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes F.","family":"Imhoff","sequence":"additional","affiliation":[{"name":"RD3 \u2010 Marine Ecology, RU \u2010 Marine Microbiology GEOMAR Helmholtz Centre for Ocean Research Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,28]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01450"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NP00052A"},{"key":"e_1_2_4_4_1","unstructured":"ECDC.2013.European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2012.Annual report of the European Antimicrobial Resistance Surveillance Network (EARS\u2010Net). Stockholm Sweden: ECDC. Retrieved fromhttp:\/\/ecdc.europa.eu\/en\/publications\/antimicrobial\u2010resistance\u2010surveillance\u2010europe\u20102012.pdf"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.3934\/microbiol.2016.2.205"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3354\/meps08607"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.2216\/12-24.1"},{"key":"e_1_2_4_8_1","first-page":"17","article-title":"Bacterial isolates from the bryozoan Membranipora membranacea: Influence of culture media on isolation and antimicrobial activity","volume":"15","author":"Heindl H.","year":"2012","journal-title":"International Microbiology"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.syapm.2009.12.002"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/md14010019"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.03.001"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-55519-0_2"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14098"},{"key":"e_1_2_4_14_1","unstructured":"MarinLit. (2018). Retrieved fromhttp:\/\/pubs.rsc.org\/marinlit"},{"key":"e_1_2_4_15_1","unstructured":"Mayer A. M. S.. (2018).Marine pharmaceuticals: The clinical pipeline. Retrieved fromhttp:\/\/marinepharmacology.midwestern.edu\/clinPipeline.htm"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.02.005"},{"key":"e_1_2_4_17_1","article-title":"Marine pharmacology in 2012\u20102013: Marine compounds with antibacterial, antidiabetic, antifungal, anti\u2010inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action","volume":"15","author":"Mayer A. M. S.","year":"2017","journal-title":"Marine Drugs"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/np800032a"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.3354\/ame01595"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-101353"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.33"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-015-0613-1"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100135b"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00780-10"},{"key":"e_1_2_4_26_1","volume-title":"Nagoya protocol on access to genetic resources and the fair and equitable sharing of benefits arising from their utilization to the convention on biological diversity","author":"Secretariat of the Convention on Biological Diversity","year":"2011"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.01.062"},{"key":"e_1_2_4_28_1","first-page":"147","volume-title":"Submariner compendium. An assessment of innovative and sustainable uses of Baltic marine resources","author":"Wiese J.","year":"2012"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/md9040561"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10126-008-9143-4"},{"key":"e_1_2_4_31_1","unstructured":"World Health Organization. (2011).European strategic action plan on antibiotic resistance(EUR\/RC61\/14). World Health Organization Regional Committee for Europe."},{"key":"e_1_2_4_32_1","unstructured":"World Health Organization. (2017).Global priority list of antibiotic\u2010resistant bacteria to guide research discovery and development of new antibiotics. World Health Organization."},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12041924"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12031208"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10126-014-9599-3"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13084617"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201600430"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddr.21482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T21:56:31Z","timestamp":1760392591000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,28]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/ddr.21482"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21482","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,28]]},"assertion":[{"value":"2018-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}