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Structurally simplified analogues of antiplasmodial active alkaloids presented similar levels of activity as their corresponding natural products extracted from <jats:italic>Guiera senegalensis<\/jats:italic> and <jats:italic>Mitragyna inermis<\/jats:italic> with IC<jats:sub>50<\/jats:sub> values on chloroquine\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>P. falciparum<\/jats:italic><\/jats:styled-content> K1 strain of up to 10.6\u2009\u03bcM for spirooxindoles and 13.8\u2009\u03bcM for \u03b2\u2010carbolines. The identification of such simpler and cheaper structural analogues is crucial to efficiently study these natural products' action mode as well as developing new cures against malaria.<\/jats:p>","DOI":"10.1002\/ddr.21494","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T02:44:45Z","timestamp":1543545885000},"page":"133-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Design and synthesis of simplified speciophylline analogues and \u03b2\u2010carbolines as active molecules against <i>Plasmodium falciparum<\/i>"],"prefix":"10.1002","volume":"80","author":[{"given":"David","family":"Pierrot","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, CNRS Centrale Marseille  iSm2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Sinou","sequence":"additional","affiliation":[{"name":"Aix Marseille University, UMR MD1  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sok\u2010Siya","family":"Bun","sequence":"additional","affiliation":[{"name":"CNRS, IRD, IMBE, FAC PHARM Aix Marseille University, Avignon Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Parzy","sequence":"additional","affiliation":[{"name":"Department of Biology K\u2010plan  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Taudon","sequence":"additional","affiliation":[{"name":"D\u00e9partement des plateformes et recherche technologique Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA)  Br\u00e9tigny\u2010sur\u2010Orge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS Centrale Marseille  iSm2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Ollivier","sequence":"additional","affiliation":[{"name":"CNRS, IRD, IMBE, FAC PHARM Aix Marseille University, Avignon Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-4626","authenticated-orcid":false,"given":"Damien","family":"Bonne","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS Centrale Marseille  iSm2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1025"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1645-1649.2000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.730"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557511313120008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np200509g"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cs401172r"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1135\/cccc20021669"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja983788i"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.806"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.12.030"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200701342"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/JR9580003639"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1135\/cccc19990408"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)98292-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2016.03.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","article-title":"Synchronization of Plasmodium falciparum erythrocytic stages in culture","volume":"95","author":"Lambros C.","year":"1979","journal-title":"The Journal of Parasitology"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2010.08.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201200808"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.08.028"},{"key":"e_1_2_7_21_1","first-page":"1","article-title":"Improvement of secondary metabolites from Phyllanthus odontadenius against malaria by mutagenesis","volume":"21","author":"Nakweti R. 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