{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:19:13Z","timestamp":1792491553749,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007487","name":"Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico","doi-asserted-by":"publisher","award":["CONACYT(83808)"],"award-info":[{"award-number":["CONACYT(83808)"]}],"id":[{"id":"10.13039\/501100007487","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trichomoniasis, caused by the protozoan parasite <jats:italic>Trichomonas vaginalis<\/jats:italic>, is the most common nonviral sexually transmitted infection worldwide. Although drug treatment is available, unpleasant side effects and increased resistance to the nitroimidazole family have been documented. Hence, there is a need for the identification of new and safe therapeutic agents against <jats:italic>T. vaginalis<\/jats:italic>. Antimicrobial activity of anthraquinone compounds has been reported by a number of authors. The genus <jats:italic>Morinda<\/jats:italic> is well known for the diversity of anthraquinones with numerous biological activities. A new anthraquinone, lucidin\u2010\u03c9\u2010isopropyl ether, was isolated from the roots of <jats:italic>Morinda panamensis<\/jats:italic> Seem. The structure of the compound was determined by <jats:sup>1<\/jats:sup>H and <jats:sup>13<\/jats:sup>C Nuclear Magnetic Resonance (NMR) analyses, in addition to comparison with literature reports. Using in vitro susceptibility assay, the half inhibitory concentration (IC<jats:sub>50<\/jats:sub>) of lucidin\u2010\u03c9\u2010isopropyl ether for <jats:italic>T. vaginalis<\/jats:italic> (1.32\u2009\u03bcg\/mL) was found similar to that of metronidazole concentration tested (6 \u03bcM\u2009=\u20091.03\u2009\u03bcg\/mL). In addition, this anthraquinone was capable of inhibiting the parasite's ability to kill HeLa cells and decreased proteolytic activity of the proteinase TvMP50 from <jats:italic>T. vaginalis<\/jats:italic>. This was associated with the decreased expression of the <jats:italic>mp50<\/jats:italic> gene. These results demonstrate the trichomonicidal potential by lucidin\u2010\u03c9\u2010isopropyl ether. Further action\u2010mode studies are necessary to elucidate the antiparasitic mechanism of this new anthraquinone to develop a more potent antitrichomonal agent.<\/jats:p>","DOI":"10.1002\/ddr.21504","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T09:02:43Z","timestamp":1545296563000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trichomonicidal activity of a new anthraquinone isolated from the roots of <i>Morinda panamensis<\/i> Seem"],"prefix":"10.1002","volume":"80","author":[{"given":"David","family":"C\u00e1ceres\u2010Castillo","sequence":"first","affiliation":[{"name":"Laboratorio de Qu\u00edmica Farmac\u00e9utica. Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Yucat\u00e1n  M\u00e9rida Yucatan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yussel","family":"P\u00e9rez\u2010Navarro","sequence":"additional","affiliation":[{"name":"Posgrado de Ciencias Gen\u00f3micas Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico  Mexico, D.F. Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C\u00e9sar","family":"Torres\u2010Romero","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica y Gen\u00e9tica Molecular. Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Yucat\u00e1n  M\u00e9rida Yucatan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gumersindo","family":"Mir\u00f3n\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Farmac\u00e9utica. Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Yucat\u00e1n  M\u00e9rida Yucatan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Ceballos\u2010Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Farmac\u00e9utica. Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Yucat\u00e1n  M\u00e9rida Yucatan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-1677","authenticated-orcid":false,"given":"Victor","family":"Arana\u2010Arg\u00e1ez","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda. 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Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Fern\u00e1ndez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad Profesional Interdisciplinaria de Biotecnolog\u00eda Instituto Polit\u00e9cnico Nacional  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-4451","authenticated-orcid":false,"given":"Mar\u00eda Elizbeth","family":"Alvarez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Posgrado de Ciencias Gen\u00f3micas Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico  Mexico, D.F. 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