{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:46:26Z","timestamp":1778337986041,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Project of Yongkang City, Zhejiang Province","award":["[201721]"],"award-info":[{"award-number":["[201721]"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Hit, Lead &amp; Candidate Discovery<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n\n<\/jats:table-wrap><\/jats:p><jats:p>This study investigated the effects of a natural phenolic compound quercetin on surgical\u2010induced osteoarthritis (OA) in rabbits. Forty\u2010eight New Zealand White rabbits were used to establish OA model by Hulth modified method, and subsequently randomized into untreated OA group (treatment was drinking water), celecoxib treated group (celecoxib 100\u2009mg\u2009kg<jats:sup>\u20111<\/jats:sup> by gavage), and quercetin treated group (25\u2009mg\u2009kg<jats:sup>\u20111<\/jats:sup> by gavage). Sixteen nonoperated rabbits served as the normal controls (drinking water was given). The treatment (length: 4 weeks) started on the 5th week postoperation when the OA pathological changes were manifested. Expressions of superoxide dismutase (SOD), matrix metalloproteinase\u201013 (MMP\u201013) and tissue inhibitor of metalloproteinases\u20101 (TIMP\u20101) in serum, synovial fluid, and synovial tissue were measured at 8 and 12\u2009weeks postoperation. Pathological analysis was performed with synovial tissue section and Osteoarthritis Research Society International histopathology grading and staging scores were determined. The quercetin treated group showed higher SOD and TIMP\u20101 expressions but lower MMP\u201013 expression than untreated OA group in the serum, synovial fluid and synovial tissues (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). There was no significant difference in the SOD, MMP\u201013 and TIMP\u20101 expressions between the quercetin\u2010treated and celecoxib\u2010treated groups. The MMP\u201013\/TIMP\u20101 ratio of the quercetin treated group was significantly lower than that of the untreated OA group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Quercetin can up\u2010regulate SOD and TIMP\u20101, down\u2010regulate MMP\u201013, and improve the degeneration of OA through weakening the oxidative stress responses and inhibiting the degradation of cartilage extracellular matrix.<\/jats:p>","DOI":"10.1002\/ddr.21510","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T14:05:39Z","timestamp":1546610739000},"page":"360-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Protective effects of quercetin against inflammation and oxidative stress in a rabbit model of knee osteoarthritis"],"prefix":"10.1002","volume":"80","author":[{"given":"Bing","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First People's Hospital of Yongkang  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Zhucheng Maternal and Child Health Hospital  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of General Diseases The First People's Hospital of Yongkang  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yikui","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First People's Hospital of Yongkang  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First People's Hospital of Yongkang  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2951-8511","authenticated-orcid":false,"given":"Xiaoke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First People's Hospital of Yongkang  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2016.08.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2825-y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.01.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200209000-00004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34497"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0682-3"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"877","article-title":"Quercetin in association with moderate exercise training attenuates injuries induced by experimental diabetes in sciatic nerves","volume":"68","author":"Chis I. 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