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MI occurs mainly due to the risk factors like smoking, elevated blood pressure, diabetes, hypercholesterolemia, obesity, decreased HDL level, elevated LDL level, hyperlipoproteinemia and aging consequently leads to demandable coronary blood supply, oxidative stress, and acute necrosis of the myocardium. Cardioprotective potential of the phloroglucinol (PG) was assessed by treating isoprenaline hydrochloride (ISO; 85\u2009mg\/kg b.w., s.c.) induced MI model in rats. Pretreatment with PG in a dose of 30\u2009mg\/kg was done for 28\u2009days and followed by ISO (for MI induction) on 29th and 30th days, exhibited decline in the abnormalities in the ECG patterns, cardiac marker enzymes, enzymic and nonenzymic antioxidants, lipid peroxidation, lipid profiles, and histopathological investigations compared to isoprenaline alone treated group. On the whole, the present investigations elucidate the significance of PG in alleviating the pathological process and appreciably prevent the induction of MI in experimental rats.<\/jats:p>","DOI":"10.1002\/ddr.21517","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:03:25Z","timestamp":1553040205000},"page":"453-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Phloroglucinol averts isoprenaline hydrochloride induced myocardial infarction in rats"],"prefix":"10.1002","volume":"80","author":[{"given":"Canzhan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University, No 157 Xiwulu,Xincheng District  Xi'an City Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University, No 157 Xiwulu,Xincheng District  Xi'an City Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University, No 157 Xiwulu,Xincheng District  Xi'an City Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahong","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University, No 157 Xiwulu,Xincheng District  Xi'an City Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University, No 157 Xiwulu,Xincheng District  Xi'an City Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University, No 157 Xiwulu,Xincheng District  Xi'an City Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University, No 157 Xiwulu,Xincheng District  Xi'an City Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-1717","authenticated-orcid":false,"given":"Mingjuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University, No 157 Xiwulu,Xincheng District  Xi'an City Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-016-0494-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.61.10.0014"},{"key":"e_1_2_7_4_1","first-page":"257","volume-title":"Membrane and ion transport","author":"Bonting S. 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