{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:52:22Z","timestamp":1790391142684,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) possess as primary action mechanism the inhibition of cyclooxygenases (COX\u20101, COX\u20102, and COX\u20103), thus producing a decreasing prostaglandin synthesis. This study was designed to evaluate whether the antinociception induced by NSAIDs could be modulated by clomipramine or risperidone using a chemical model of inflammatory acute visceral pain, the abdominal acetic acid induced a writhing test in mice. Dose\u2013response curves, intraperitoneal, or intrathecal for the antinociceptive activity displayed by ketoprofen, piroxicam, nimesulide, parecoxib, and paracetamol were analyzed in order to obtain the ED<jats:sub>50<\/jats:sub> of each drug. Pretreatment of mice with either clomipramine or risperidone, increased antinociceptive potency of ketoprofen, piroxicam, nimesulide, parecoxib, and paracetamol, expressed by a decrease in the values of antinociceptive ED<jats:sub>50.<\/jats:sub><\/jats:p><jats:p>The results that were obtained are in line with those where the inhibition of COXs provides a justification for most of the pharmacological actions. Nevertheless, several findings suggest other molecular mechanisms, among which may be mentioned, L\u2010selecting shedding; inhibition of i\u2010NOS; inhibition of NF\u2010Kappa B; suppression metaloproteinasas; inhibition of \u00df2 integrin activation; activation of \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor; increase of IL\u20101\u00df; upregulation IL\u20106. In conclusion, the data generated in this study demonstrated that risperidone and clomipramine, separately, increase antinociceptive potency of NSAIDs in a chemical model of inflammatory acute visceral tonic pain.<\/jats:p>","DOI":"10.1002\/ddr.21519","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T23:52:30Z","timestamp":1550188350000},"page":"471-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pharmacological interaction between NSAIDS with clomipramine and risperidone in mice visceral pain"],"prefix":"10.1002","volume":"80","author":[{"given":"Claudio Gonzalez","family":"Vargas","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Chemistry and Pharmacy Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5199-1719","authenticated-orcid":false,"given":"Hugo F.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Faculty of Medicine Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Sierralta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Pharmacology Program, ICBM Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Noriega","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Clinical Hospital Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Pharmacology Program, ICBM Universidad de Chile Santiago Chile"},{"name":"Cardiovascular Department, Clinical Hospital Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.169276"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000207"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-017-0073-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.07.027"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-015-0092-x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170911121027"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.12.016"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.03.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445222"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707253"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-013-0172-x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2018.0010"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467210902010001"},{"key":"e_1_2_5_15_1","first-page":"28","article-title":"Antinociceptive potentiation of pethidine (demerol) by clomipramine in the late phase of formalin test in mice","volume":"12","author":"Kariuki H. 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