{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:04:31Z","timestamp":1760486671969,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007611","name":"Shiv Nadar University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007611","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antimicrobial drug resistance is one of the most critical problems that plagued the human race in modern times. Discovery of novel antibiotics is important to counter this threat. Accordingly, herein we have reported the discovery of substituted benzimidazole class of molecules with antimicrobial property (specifically against <jats:italic>Staphylococcus aureus<\/jats:italic>). They were initially identified through a random screening and a novel catalytic synthetic strategy was utilized to access them. in vitro screening and phenotypic profiling revealed the antimicrobial nature. De novo transcriptome and gene analyses predicted the putative targets. This work provides a solid foundation for developing the benzimidazoles as a target specific antimicrobial preclinical candidate.<\/jats:p>","DOI":"10.1002\/ddr.21523","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T02:17:45Z","timestamp":1550801865000},"page":"490-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Transcriptome analysis predicts mode of action of benzimidazole molecules against <i>Staphylococcus aureus<\/i> UAMS\u20101"],"prefix":"10.1002","volume":"80","author":[{"given":"Deepika","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Life Science, School of Natural Sciences Shiv Nadar University  Dadri Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santanu","family":"Hati","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Natural Sciences Shiv Nadar University  Dadri Uttar Pradesh India"},{"name":"Department of Medicinal Chemistry, College of Pharmacy University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Priyadarshini","sequence":"additional","affiliation":[{"name":"Department of Life Science, School of Natural Sciences Shiv Nadar University  Dadri Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4608-5498","authenticated-orcid":false,"given":"Subhabrata","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Natural Sciences Shiv Nadar University  Dadri Uttar Pradesh India"},{"name":"Department of Chemistry SRM University  Amaravati Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1076\/1388-0209(200009)38:4;1-A;FT298"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.099"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.04.037"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1500292"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5362.438"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NJ01858G"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA24939F"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA19255B"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.423507"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2693"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja2039979"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/51201429"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(03)00058-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b01217"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201601419"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159961"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr490"},{"key":"e_1_2_7_19_1","unstructured":"Joshi N. A. &Fass J. N.(2011). Sickle: A sliding\u2010window adaptive quality\u2010based trimming tool for FastQ files (Version 1.33) [Software]."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.1.22"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.15.1763"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01743-08"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0748985"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808203390806"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5428.760"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101560100034"},{"issue":"47","key":"e_1_2_7_29_1","doi-asserted-by":"crossref","DOI":"10.3791\/2437","article-title":"Microtiter dish biofilm formation assay","author":"O'Toole G. A.","year":"2011","journal-title":"Journal of Visualized Experiments: JoVE"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2787623"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.08.005"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot5439"},{"issue":"1","key":"e_1_2_7_33_1","first-page":"e01584","article-title":"Genome sequence of the clinical isolate Staphylococcus aureus subsp. aureus Strain UAMS\u20101","volume":"23","author":"Sassi M.","year":"2015","journal-title":"Genome Announcements"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05321-1"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00134-14"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.06.026"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.179"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090956"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.521"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddr.21523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.21523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T23:34:34Z","timestamp":1760398474000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,21]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/ddr.21523"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21523","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"type":"print","value":"0272-4391"},{"type":"electronic","value":"1098-2299"}],"subject":[],"published":{"date-parts":[[2019,2,21]]},"assertion":[{"value":"2018-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}