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Combinatorial drug therapy may overcome these limitations by permitting lower doses and more specific targeting, thereby mitigating drug resistance and nontarget side effects. Recent reports indicate that nonsteroidal anti\u2010inflammatory drugs (NSAIDs) have anticancer potential and can be used together with conventional chemotherapeutics to improve efficacy and safety. In the present study, imatinib mesylate and dexketoprofen trometamol were selected as model drugs to develop targeted surface\u2010modified liposome and nanocochleate formulations for fibrosarcoma treatment. The physicochemical properties and in vitro efficacy of various formulations were evaluated by measurement of particle size distribution, polydispersity index, zeta potential, encapsulation efficiency, diffusion through Caco\u20102 cells, and toxicity in culture. Selected formulations were then evaluated in fibrosarcoma\u2010bearing model mice by histopathological observations and tyrosine kinase receptor inhibition assays. The most effective formulation on the fibrosarcoma model was a PEGylated nanocochleate formulation. These findings provide a foundation for developing more effective formulations and chemotherapeutic strategies for the treatment of fibrosarcoma and other types of cancer.<\/jats:p>","DOI":"10.1002\/ddr.21530","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T12:02:24Z","timestamp":1553256144000},"page":"556-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma"],"prefix":"10.1002","volume":"80","author":[{"given":"\u00d6zlem","family":"\u00c7oban","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology Karadeniz Technical University Faculty of Pharmacy  Trabzon Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2596-3615","authenticated-orcid":false,"given":"Zelihag\u00fcl","family":"De\u011fim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Biruni University Faculty of Pharmacy  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e\u00fckran","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Cell Bank, Food and Mouth Diseases Institute  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Alt\u0131nta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Ankara University Faculty of Veterinary Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taibe","family":"Arsoy","sequence":"additional","affiliation":[{"name":"Department of Cell Bank, Food and Mouth Diseases Institute  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"S\u00f6zmen","sequence":"additional","affiliation":[{"name":"Department of Preclinical Sciences OndokuzMay\u0131s University, Faculty of Veterinary Medicine  Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.04.050"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018936806278"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"68","article-title":"The effect of celecoxib and its combination with imatinib on human HT\u201029 colorectal cancer cells: Involvement of COX\u20102, Caspase\u20103, VEGF and NF\u2010\u03baB genes expression","volume":"62","author":"Atari\u2010Hajipirloo S.","year":"2016","journal-title":"Cellular and Molecular Biology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2010.29.6.891"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.08.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.08.027"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2017.06.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2007.10.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.12.055"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1941"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17055972"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"1","article-title":"Preparation and evaluation of PEGylated and folate\u2010PEGylated liposomes containing paclitaxel for lymphatic delivery","volume":"16","author":"Cho H. 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