{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:25:49Z","timestamp":1787160349478,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Novel bioactive compounds as synthetic analogs of the potent herbal medicines can be optimized as potential drug candidates for various neurologic disorders. This study was performed to investigate the newly synthesized dibenzylidene ketone derivatives: (2E,6E)\u20102,6\u2010dibenzylidene cyclohexanone (A1K1) and (1E,4E)\u20105\u2010(2,3\u2010dichlorophenyl)\u20101\u2010(4\u2010methoxyphenyl)\u20102\u2010methylpenta\u20101,4\u2010diene\u20103\u2010one (A2K2) and evaluate its potential anti\u2010Alzheimer's and anti\u2010depressant properties. Both the derivatives are chemically characterized by using HNMR and CNMR techniques. Auto Dock Vina program was used to investigate ligand\u2010protein affinity. Forced swim test, tail suspension test, open field test, Y\u2010maze test, and Morris water maze test (MWM) models were employed to evaluate anti\u2010depressant and anti\u2010Alzheimer's activity of dibenzylidene ketone derivatives in mice. Both A1K1 and A2K2 showed high binding affinities against various proteins involved in depression and Alzheimer's mechanisms like monoamine oxidase B, acetylcholinesterase, norepinephrine transporter 2, serotonin transporter, dopamine receptor, serotonin receptor modulator, and beta\u2010amyloid targets. A1K1 and A2K2 dose\u2010dependently (0.1\u20131 mg\/kg) decreased immobility time, while increased swimming and climbing time of mice in forced swim test (FST). A1K1 and A2K2 decreased animal immobility time in TST. In the open field test, both A1K1 and A2K2 increased the number of ambulations and rearings. A1K1 and A2K2 dose\u2010dependently (0.5\u20131.0 mg\/kg) increased spontaneous alternation behavior (%) and the number of entries of mice in Y\u2010maze test. In the MWM test, A1K1 and A2K2 decreased escape latency time. Overall, both\n                    <jats:italic>in\u2010silico<\/jats:italic>\n                    and in\u2010vivo investigations of A1K1 and A2K2, report their therapeutic potential for antidepressant and anti\u2010Alzheimer properties. Hence, these compounds possess potent neuroprotective properties and may be further evaluated for their therapeutic potential in various neurological disorders.\n                  <\/jats:p>","DOI":"10.1002\/ddr.21537","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T11:11:54Z","timestamp":1554808314000},"page":"595-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Synthesis, characterization, molecular docking evaluation, antidepressant, and anti\u2010Alzheimer effects of dibenzylidene ketone derivatives"],"prefix":"10.1002","volume":"80","author":[{"given":"Muhammad Adnan","family":"Bashir","sequence":"first","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences Riphah International University  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif\u2010ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences Riphah International University  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-0414","authenticated-orcid":false,"given":"Haroon","family":"Badshah","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences Riphah International University  Islamabad Pakistan"},{"name":"Department of Pharmacy Abdul Wali Khan University  Mardan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Rodrigues\u2010Filho","sequence":"additional","affiliation":[{"name":"Departament of Chemistry Federal University of Sao Carlos  S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zia Ud","family":"Din","sequence":"additional","affiliation":[{"name":"Departament of Chemistry Federal University of Sao Carlos  S\u00e3o Carlos S\u00e3o Paulo Brazil"},{"name":"Department of Chemistry Woman University Swabi  Swabi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslam","family":"Khan","sequence":"additional","affiliation":[{"name":"Basic Sciences Department College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs  Jeddah Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21435"},{"issue":"6","key":"e_1_2_9_3_1","first-page":"266","article-title":"Neuroprotective effect of ceftriaxone and Selegiline on scopolamine induced cognitive impairment in mice","volume":"7","author":"Akina S.","year":"2013","journal-title":"Advances in Biological Research"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12194"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1846"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.040"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00176837"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021694307672"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00304-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.08.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0166-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2269-7_19"},{"issue":"6","key":"e_1_2_9_14_1","first-page":"7","article-title":"Depression: The case for a monoamine deficiency","volume":"61","author":"Delgado P. L.","year":"2000","journal-title":"The Journal of Clinical Psychiatry"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245592"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/974308"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573401313666170725103932"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0198-097"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2009.02.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1020-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt277"},{"key":"e_1_2_9_22_1","first-page":"121","article-title":"Animal Models of Depression: Molecular Perspectives. Current Topics in Behavioral","volume":"7","author":"Krishnan V.","year":"2011","journal-title":"Neurosciences"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-003-0743-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep232"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.40220"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90007-4"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00810-9"},{"key":"e_1_2_9_28_1","first-page":"3","volume-title":"Clinical Pharmacology","author":"Rang H.","year":"2003"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.660"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/974308"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2006.08.018"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.116"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016357811882"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.21537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:07:22Z","timestamp":1760364442000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,9]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/ddr.21537"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21537","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,9]]},"assertion":[{"value":"2018-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}