{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:26:26Z","timestamp":1774473986609,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system. Although the exact etiology of the disease is largely unknown, it is identified that cytokines may play an important role in the pathogenesis of MS. In this study, the effects of curcumin has been investigated on the expression levels of selected cytokine coding genes as well as the extent of demyelination in the corpus callosum of C57BL\/6 experimental autoimmune encephalomyelitis (EAE) model of MS. Gene expression analyses revealed that treatment with curcumin could lead to a significant reduction in the expression levels of pro\u2010inflammatory cytokine coding genes including <jats:italic>IL\u20106<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.001), <jats:italic>IL\u201017<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.001), tumor necrosis factor (<jats:italic>TNF<\/jats:italic>)\u2010<jats:italic>\u03b1<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.008), and interferon (<jats:italic>IFN<\/jats:italic>)\u2010<jats:italic>\u03b3<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.033) as well as a significant increase in the expression level of transforming growth factor (<jats:italic>TGF<\/jats:italic>)\u2010<jats:italic>\u03b2<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.006) as an anti\u2010inflammatory cytokine. Moreover, the expression of glutathione peroxidase (<jats:italic>GPX<\/jats:italic>)\u20101 gene and the activity of anti\u2010oxidant enzymes were significantly higher (<jats:italic>p<\/jats:italic> &lt; 0.001) in curcumin\u2010treated mice. Luxol fast blue staining also confirmed a significant reduction in the extent of demyelination in the curcumin\u2010treated group (<jats:italic>p<\/jats:italic> &lt; 0.001). Our results have confirmed that curcumin is an effective therapeutic agent that could ameliorate the severity of EAE.<\/jats:p>","DOI":"10.1002\/ddr.21540","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T07:52:03Z","timestamp":1556524323000},"page":"629-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Curcumin ameliorates experimental autoimmune encephalomyelitis in a C57BL\/6 mouse model"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4519-8298","authenticated-orcid":false,"given":"Emran","family":"Esmaeilzadeh","sequence":"first","affiliation":[{"name":"Genetics Research Center University of Social Welfare and Rehabilitation Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Department of basic science University of Social Welfare and Rehabilitation Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davood","family":"Zare\u2010Abdollahi","sequence":"additional","affiliation":[{"name":"Genetics Research Center University of Social Welfare and Rehabilitation Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnamedin","family":"Jameie","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Khorram Khorshid","sequence":"additional","affiliation":[{"name":"Genetics Research Center University of Social Welfare and Rehabilitation Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.06.010"},{"key":"e_1_2_7_3_1","first-page":"1201","article-title":"Management of chronic anterior uveitis relapses: Efficacy of oral phospholipidic curcumin treatment. 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