{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:05:15Z","timestamp":1760403915769,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673336"],"award-info":[{"award-number":["81673336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009334","name":"Pearl River S and T Nova Program of Guangzhou","doi-asserted-by":"publisher","award":["201806010116"],"award-info":[{"award-number":["201806010116"]}],"id":[{"id":"10.13039\/501100009334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence of multidrug resistance among clinically significant bacterial pathogens underlines a critical need for the development of new classes of antibacterial agents with novel structural scaffolds. Cajaninstilbene acid (CSA), which is isolated from pigeonpea leaves, has shown potent antibacterial activity. In this study, a series of 2\u2010hydroxyl\u20104\u2010methoxyl\u20103\u2010(3\u2010methylbut\u20102\u2010en\u20101\u2010yl)\u20106\u2010(4\u2010phenylbenzoylamino)benzoic acid derivatives derived from CSA were designed and synthesized, and their antibacterial activities were evaluated. Several synthesized compounds exhibit better antibacterial activity than CSA against <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Staphylococcus epidermidis<\/jats:italic>, and two strains of methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic>. Meanwhile, the results of 3\u2010[4,5\u2010dimethylthiazol\u20102\u2010yl]\u20102,5\u2010diphenyl tetrazolium bromide assays illustrate the good selectivity between bacteria and normal cells of the most active compounds <jats:bold>6u<\/jats:bold> and <jats:bold>6v<\/jats:bold>. Furthermore, well combinations with bacterial RNA polymerase of <jats:bold>6u<\/jats:bold> arising from docking study imply the possible mechanism of antibacterial activity of these synthetic compounds.<\/jats:p>","DOI":"10.1002\/ddr.21556","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T10:15:30Z","timestamp":1559816130000},"page":"750-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design and synthesis of 2\u2010hydroxyl\u20104\u2010methoxyl\u20103\u2010(3\u2010methylbut\u20102\u2010en\u20101\u2010yl)\u20106\u2010(4\u2010phenylbenzoylamino)benzoic acid derivatives as antibacterial agents based on cajaninstilbene acid scaffold hopping"],"prefix":"10.1002","volume":"80","author":[{"given":"Chang","family":"Zheng","sequence":"first","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Fang","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping\u2010Hua","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0292-7841","authenticated-orcid":false,"given":"Wei\u2010Min","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1021\/jm501050e"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.2174\/15748847113089990062"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1016\/S0924-8579(10)70003-0"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1016\/j.ejmech.2015.06.008"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1021\/jm400485e"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1021\/acs.jafc.6b00227"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1016\/j.ejmech.2013.01.010"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1021\/jm3012728"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1016\/j.foodchem.2010.01.062"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1021\/ml200087m"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.2147\/DDDT.S149973"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1021\/cr030101q"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1021\/jm031140x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1021\/jm049141s"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1021\/acs.orglett.5b00983"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1038\/nrmicro2349"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1021\/acschembio.7b00175"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.1021\/jm4006302"},{"issue":"4","key":"e_1_2_7_20_1","first-page":"238","article-title":"Antimicrobial resistance: Global report on surveillance","volume":"7","author":"World Health Organization","year":"2014","journal-title":"Australasian Medical Journal"},{"doi-asserted-by":"publisher","key":"e_1_2_7_21_1","DOI":"10.1021\/acs.jnatprod.8b00315"},{"issue":"4","key":"e_1_2_7_22_1","first-page":"1238","article-title":"Recent advances in scaffold hopping","volume":"60","author":"Ye H.","year":"2016","journal-title":"Journal of Medicinal Chemistry"},{"doi-asserted-by":"publisher","key":"e_1_2_7_23_1","DOI":"10.1021\/ol005654r"},{"doi-asserted-by":"publisher","key":"e_1_2_7_24_1","DOI":"10.1021\/jf205097y"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.21556","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T21:21:31Z","timestamp":1760390491000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/ddr.21556"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21556","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"type":"print","value":"0272-4391"},{"type":"electronic","value":"1098-2299"}],"subject":[],"published":{"date-parts":[[2019,6,6]]},"assertion":[{"value":"2018-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}