{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:06:38Z","timestamp":1760403998346,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ilkogen Pharmaceuticals","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neutropenia is a condition of an abnormally low number of neutrophils which render patients more susceptible to infections, especially to bacterial infections, as the condition may become life threatening and deadly without prompt medical attention. Various factors such as, anticancer drugs, radiotherapy, infectious diseases, congenital defects, or vitamin B12\/B9 deficiency can trigger neutropenia. GX\u2010G3, a human hybrid (hy) Fc\u2010fused granulocyte colony stimulating factor (G\u2010CSF), was developed as next\u2010generation G\u2010CSF for the treatment of cancer therapy\u2010induced neutropenia. In this study, with the aim of investigating this promising potential next\u2010generation G\u2010CSF, comparative pharmacokinetic and pharmacodynamic studies were conducted in healthy and neutropenia\u2010induced rats. It was found that <jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub> of GX\u2010G3 is longer than same mass injection of filgrastim and pegfilgrastim and <jats:italic>AUEC<\/jats:italic><jats:sub>last<\/jats:sub> (area under theeffect\u2010time curve from time zero to the last measurable ANC level) of absolute neutrophil count showed a significant increase after GX\u2010G3 injection compared with filgrastim and pegfilgrastim in healthy rats. Besides, in duration of neutropenia after the same mass injection GX\u2010G3 showed about 3.3 days of reduction effect compared with that of filgrastim, and 1.3 days of reduction effect compared with that of pegfilgrastim in neutropenia\u2010induced rats. These results demonstrate that the half\u2010life of GX\u2010G3 is longer than pegfilgrastim and GX\u2010G3 is more effective than filgrastim and pegfilgrastim in neutropenia\u2010induced rats.<\/jats:p>","DOI":"10.1002\/ddr.21563","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T07:31:18Z","timestamp":1562830278000},"page":"807-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preclinical evaluation of a biobetter candidate: Pharmacokinetics and pharmacodynamics of GX\u2010G3 in healthy and neutropenia\u2010induced rats"],"prefix":"10.1002","volume":"80","author":[{"given":"Yun Jung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Bio\u2010institute Genexine, Inc.  Seongnam Gyeonggi, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senem","family":"Ertan\u2010Ahmed","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Ilkogen Pharmaceuticals  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-9018","authenticated-orcid":false,"given":"Yilmaz","family":"Capan","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Ilko Pharmaceuticals  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang In","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010institute Genexine, Inc.  Seongnam Gyeonggi, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.3.5.17334"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/shem.2002.31911"},{"key":"e_1_2_8_4_1","unstructured":"ClinicalKey. (2019).Drug Monograph Pegfilgrastim (Fulphila | Neulasta). 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