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DOXY\u2010containing modified\u2010release oral pellets (DMOP) coated with hydroxypropyl methylcellulose phthalate HP\u201055 (HPMCP HP\u201055) and hydroxypropyl methylcellulose E15 (HPMC E15) appear to be a reasonable choice. This coating layer dissolves at pH 5.5, which is the pH of the duodenum, but not at a gastric pH (1.2). The formulation and preparation of DMOP were optimized, and a scale\u2010up test was performed. The results showed that the production reproducibility was acceptable, and the quality of DMOP well met the standards of Chinese Pharmacopeia (Ch.P, 2015 edition). Notably, the accumulated DOXY release was lower than 50% at pH 1.2 (20\u2009min) and higher than 85% at pH 5.5, which met the USP40\u2010NF35 standard for DOXY modified\u2010release formulations. Moreover, the storage stability of DMOP with different packages was investigated by stress testing, accelerated and long\u2010term testings. The stability of DMOP was maintained up to 12\u2009months, in terms of DOXY content and in vitro release behavior. The results seem to suggest that DMOP could be a promising duodenum delivery system.<\/jats:p>","DOI":"10.1002\/ddr.21575","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:22:31Z","timestamp":1564446151000},"page":"958-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modified\u2010release oral pellets for duodenum delivery of doxycycline hyclate"],"prefix":"10.1002","volume":"80","author":[{"given":"Ying","family":"Huang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwei","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjun","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanpeng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuequn","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Memorial University of Newfoundland  St. John's Newfoundland and Labrador Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Memorial University of Newfoundland  St. John's Newfoundland and Labrador Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanbin","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl224"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12488"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2016.1178769"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24696"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013398"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/492030"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0560.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cherd.2018.02.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.10.005"},{"issue":"12","key":"e_1_2_8_11_1","first-page":"3219","article-title":"Improving access to appropriate post\u2010exposure doxycycline for Lyme disease prophylaxis: Role for community pharmacies","volume":"73","author":"Dering\u2010Anderson A. 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