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Transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) is a potent inducer of the EMT while curcumin, a diarylheptanoid, can inhibit the EMT of hepatocytes in many liver diseases. However, the protection and underlying mechanisms of curcumin against the EMT of BECs have not been clarified. Herein, we show that curcumin treatment significantly mitigates the EMT of BECs in vitro and in vivo. Mechanistically, curcumin significantly attenuated the TGF\u2010\u03b21\u2010induced Smad and Hedgehog signaling, and upregulated CD109 expression in BECs. Collectively, these findings highlighted the therapeutic potential of curcumin to counteract the EMT process in PBC.<\/jats:p>","DOI":"10.1002\/ddr.21580","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T06:35:36Z","timestamp":1565591736000},"page":"992-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Curcumin mitigates the epithelial\u2010to\u2010mesenchymal transition in biliary epithelial cells through upregulating CD109 expression"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-5968","authenticated-orcid":false,"given":"Junyu","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine Huashan Hospital Affiliated to Fudan University  Shanghai 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