{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:05:22Z","timestamp":1784559922150,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:sc>l<\/jats:sc>\u2010Arginine\u2010nitric oxide pathway has been reported to be involved in the mediation of the psychopharmacological effects of many psychotropic drugs. Previous studies have shown that morin, a psychotropic compound isolated from mulberry leaf produces functional psychopharmacological effects indicative of antidepressant, antipsychotic, anxiolytic and nootropic properties. However, the role of <jats:sc>l<\/jats:sc>\u2010arginine\u2010nitric oxide pathway in the psychotropic effects of morin has not been fully investigated, hence, the need for this study. Male Swiss mice were pretreated individually or in combination with nitric oxide precursor [<jats:sc>l<\/jats:sc>\u2010arginine (750\u2009mg\/kg, i.p.)], competitive nonselective nitric oxide synthase (NOS) inhibitor [N(G)\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine methyl ester (<jats:sc>l<\/jats:sc>\u2010NAME, i.p) (50\u2009mg\/kg)] or selective neuronal NOS inhibitor [methylene blue (3.75\u2009mg\/kg, i.p)] prior to morin (100\u2009mg\/kg, i.p.) or saline (10 mL\/kg, i.p.) treatment. Psychopharmacological activities were then evaluated 30\u2009min later using open field, Y\u2010maze, and forced swim tests. <jats:sc>l<\/jats:sc>\u2010Arginine significantly reversed the effects of morin on locomotion, memory and depression in mice. The reduced motor activity and enhanced memory function produced by morin were significantly attenuated by methylene blue but augmented the antimobility activity of morin in the FST. Moreover, <jats:sc>l<\/jats:sc>\u2010NAME potentiated the psychopharmacological effects of morin in the open field and forced swim tests but reduced its memory promoting effect. Meanwhile, morin supplementation reversed the effects of <jats:sc>l<\/jats:sc>\u2010arginine on <jats:sc>l<\/jats:sc>\u2010NAME\u2010treated mice in all behavioral models. The results of this study suggest that <jats:sc>l<\/jats:sc>\u2010arginine\u2010nitric oxide pathway might play a role in the modulation of the antidepressant and memory promoting effects of morin in mice.<\/jats:p>","DOI":"10.1002\/ddr.21588","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T01:45:59Z","timestamp":1565660759000},"page":"1071-1079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Involvement of <scp>l<\/scp>\u2010arginine\u2010nitric oxide pathway in the antidepressant and memory promoting effects of morin in mice"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3569-3575","authenticated-orcid":false,"given":"Benneth","family":"Ben\u2010Azu","sequence":"first","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics College of Medicine, University of Ibadan  Ibadan Oyo State 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