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MDD patients have a significantly impaired quality of life and reduced life expectancy compared to unaffected individuals, the latter being largely accounted for by an increased incidence of suicide and cardiovascular disorders. The premature mortality observed in MDD has been considered a signature of accelerated aging, a hypothesis supported by data showing altered functioning and morphology of several brain regions that are typically present in the aging population. Telomere shortening is a hallmark of cellular aging, and as such several studies explored the involvement of disrupted telomere dynamics in MDD, reporting contrasting findings. In the current study, we measured leukocyte telomere length (LTL) in a sample of 54 MDD patients and 47 non\u2010psychiatric controls characterized for response to antidepressant treatment. After correcting for age, sex, and body mass index, we showed significantly reduced LTL in affected individuals compared to controls (beta = \u2212.22, <jats:italic>p<\/jats:italic> = .02). There was no difference in LTL between treatment resistant or responsive MDD patients. Moreover, we observed no correlation between lifetime exposure to antidepressants and LTL. Our study showed that MDD patients have shorter telomeres compared to controls, supporting the hypothesis of accelerated aging in this disorder. However, LTL seemed not to be influenced by antidepressant treatment or to correlate with clinical response to these antidepressants. Further investigations in larger samples and possibly with longitudinal design are warranted to elucidate the role of altered telomere dynamics in MDD.<\/jats:p>","DOI":"10.1002\/ddr.21612","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T09:42:05Z","timestamp":1572601325000},"page":"268-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Leukocyte telomere length is reduced in patients with major depressive disorder"],"prefix":"10.1002","volume":"81","author":[{"given":"Claudia","family":"Pisanu","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia Eirini","family":"Tsermpini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Patras School of Health Sciences  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Skokou","sequence":"additional","affiliation":[{"name":"Psychiatric Clinic, Patras General Hospital  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Kordou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Patras School of Health Sciences  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippos","family":"Gourzis","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Patras School of Health Sciences  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Assimakopoulos","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Patras School of Health Sciences  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Congiu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Meloni","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Balasopoulos","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Patras School of Health Sciences  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George P.","family":"Patrinos","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Patras School of Health Sciences  Patras Greece"},{"name":"Department of Pathology United Arab Emirates University, College of Medicine and Health Sciences  Al\u2010Ain UAE"},{"name":"Zayed Center of Health Sciences United Arab Emirates University  Al\u2010Ain UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-7607","authenticated-orcid":false,"given":"Alessio","family":"Squassina","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080697"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1006-1133"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00473-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170838"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20128"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0289-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2602"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000356"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.10.1156"},{"issue":"8","key":"e_1_2_7_11_1","first-page":"1327","article-title":"Age\u2010related total gray matter and white matter changes in normal adult brain. 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