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All the synthesized derivatives were evaluated for their antibacterial activities against <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content>, <jats:styled-content style=\"fixed-case\"><jats:italic>Pseudomonas aeruginosa<\/jats:italic>,<\/jats:styled-content> and vancomycin\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>P. aeruginosa<\/jats:italic><\/jats:styled-content>. They were found to be more active on <jats:styled-content style=\"fixed-case\"><jats:italic>P. aeruginosa<\/jats:italic><\/jats:styled-content> than on <jats:styled-content style=\"fixed-case\"><jats:italic>S. aureus<\/jats:italic><\/jats:styled-content>. However, they did not exhibit potent activity on Vancomycin resistant <jats:styled-content style=\"fixed-case\"><jats:italic>P. aeruginosa<\/jats:italic><\/jats:styled-content>. Among the tested compounds, methylenedioxycinnamic acid amide of anthranilic acid (MDCA\u2010AA, 2a) was found to be most active against <jats:styled-content style=\"fixed-case\"><jats:italic>S. aureus<\/jats:italic><\/jats:styled-content> with MIC of 3.125 \u03bcg\/ml. The PAS and INH amides of piperic acid were screened against <jats:italic>Mycobacterium tuberculosis H37R<\/jats:italic><jats:sub>a<\/jats:sub> strain. They were found to be most active among all the tested compounds but were found to be less active than the standard drug, isoniazid.<\/jats:p>","DOI":"10.1002\/ddr.21630","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T08:45:25Z","timestamp":1575449125000},"page":"366-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and antimicrobial evaluation of piperic acid amides and their lower homologues"],"prefix":"10.1002","volume":"81","author":[{"given":"Prabhakar S.","family":"Achanta","sequence":"first","affiliation":[{"name":"University College of Pharmaceutical Sciences, Kakatiya University  Warangal Urban Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Microbiology CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyar","family":"Horam","sequence":"additional","affiliation":[{"name":"Department of Microbiology CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesu","family":"Arockiaraj","sequence":"additional","affiliation":[{"name":"Division of Fisheries Biotechnology &amp; Molecular Biology, Department of Biotechnology, Faculty of Science and Humanities SRM University  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi Kumar","family":"Bobbala","sequence":"additional","affiliation":[{"name":"University College of Pharmaceutical Sciences, Kakatiya University  Warangal Urban Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghuram Rao","family":"Akkinepally","sequence":"additional","affiliation":[{"name":"University College of Pharmaceutical Sciences, Kakatiya University  Warangal Urban Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukesh","family":"Pasupuleti","sequence":"additional","affiliation":[{"name":"Department of Microbiology CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-8833","authenticated-orcid":false,"given":"Appa Rao V. 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