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There are limitations in the current therapies for liver fibrosis. Recently, oridonin was shown to induce apoptosis in HSCs. Thus, we aimed to determine the roles of oridonin in chronic liver injury and fibrosis. Liver fibrosis was induced by CCl<jats:sub>4<\/jats:sub> in mice injected intraperitoneally with oridonin for 6\u2009weeks. The administration of oridonin significantly attenuated liver injury and reduced ALT levels. In addition, Sirius Red staining and the expression of \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) were significantly reduced by oridonin in murine livers with fibrosis. The expression of NLRP3, caspase\u20101, and IL\u20101\u03b2 was downregulated with the oridonin treatment. Furthermore, the expression of F4\/80 in liver tissues was also decreased by oridonin treatment. These results demonstrate that oridonin ameliorates chronic liver injury and fibrosis. Mechanically, oridonin may inhibit the activity of the NLRP3 inflammasome and inflammation in the liver. These results highlight the potential of oridonin as a therapeutic agent for liver fibrosis.<\/jats:p>","DOI":"10.1002\/ddr.21649","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T23:21:16Z","timestamp":1585264876000},"page":"526-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Oridonin ameliorates carbon tetrachloride\u2010induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome"],"prefix":"10.1002","volume":"81","author":[{"given":"Dong","family":"Liu","sequence":"first","affiliation":[{"name":"College of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixian","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food and Pharmacy Engineering Guiyang University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Du","sequence":"additional","affiliation":[{"name":"College of Food and Pharmacy Engineering Guiyang University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-8555","authenticated-orcid":false,"given":"Xuelin","family":"Yun","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1601350"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524282C1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.03.036"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.07.042"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2562-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.11.035"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6137420"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2018.06.040"},{"issue":"9","key":"e_1_2_8_10_1","first-page":"4271","article-title":"Oridonin ameliorates lipopolysaccharide\/D\u2010galactosamine\u2010induced acute liver injury in mice via inhibition of apoptosis","volume":"9","author":"Deng Y.","year":"2017","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.06.015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4753"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000329"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.12.024"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9321-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04947-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130246"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30252"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88881"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19033327"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29885"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.02.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7808656"},{"issue":"2","key":"e_1_2_8_24_1","first-page":"126","article-title":"Nod\u2010like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells","volume":"16","author":"Wang H.","year":"2016","journal-title":"Bosnian Journal of Basic Medical Sciences"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.06.011"},{"issue":"5","key":"e_1_2_8_26_1","first-page":"S\u2010950","article-title":"Sa1683 enhanced anti\u2010fibrogenic effects of novel Oridonin derivative CYD0692 in hepatic stellate cells","volume":"146","author":"Wang X. 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