{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:04:48Z","timestamp":1769601888555,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the 12th 5-year Plan National Science and Technology Key Project of China","award":["2012ZX10002-004"],"award-info":[{"award-number":["2012ZX10002-004"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to assess the protective effect of nitroglycerin, a commonly used drug in cardiovascular diseases, on mice with acute liver injury induced by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). The mice were randomly divided into three groups: control, CCl<jats:sub>4<\/jats:sub>, and CCl<jats:sub>4<\/jats:sub>\u2009+\u2009nitroglycerin. They were killed at 0, 6, 12, 24, and 48\u2009h after treatment. Blood and liver tissue samples were collected for analysis. Analysis of the amounts of serum alanine aminotransferase (ALT)\/aspartate aminotransferase (AST), hepatic glutathione (GSH), and malondialdehyde (MDA) showed that nitroglycerin protected against CCl<jats:sub>4<\/jats:sub>\u2010induced acute liver injury. Liver histological analysis provided further evidence of the protective effect of nitroglycerin. Furthermore, we found that nitroglycerin suppressed the increase of T helper 17 (Th17) cells in CCl<jats:sub>4<\/jats:sub>\u2010induced acute liver injury mice. The results indicate that nitroglycerin is a potential candidate for hepatic disease.<\/jats:p>","DOI":"10.1002\/ddr.21653","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T05:01:24Z","timestamp":1584334884000},"page":"557-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nitroglycerin ameliorates liver injury and regulates adaptive immunity in mice"],"prefix":"10.1002","volume":"81","author":[{"given":"Shuang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Infectious Disease The First Affiliated Hospital of Soochow University  Suzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong\u2010Hua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Liver Disease Wuxi No. 5 People's Hospital Affiliated to Jiangnan University  Wuxi Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan\u2010Juan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The First Affiliated Hospital of Soochow University  Suzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The First Affiliated Hospital of Soochow University  Suzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The First Affiliated Hospital of Soochow University  Suzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2491-1357","authenticated-orcid":false,"given":"Jian\u2010He","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The First Affiliated Hospital of Soochow University  Suzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.469"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.41"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00171"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000463"},{"key":"e_1_2_9_6_1","first-page":"158","volume-title":"Practical approach to paediatric gastroenterology, hepatology and nutrition","author":"Bremner R.","year":"2014"},{"issue":"2","key":"e_1_2_9_7_1","article-title":"Leea macrophylla (roxb.) root extract reverses CCl4 induced liver injury through upregulation of antioxidative gene expression: A molecular interaction for therapeutic inception","author":"Bulbul M. R. H.","year":"2019","journal-title":"Oriental Pharmacy and Experimental Medicine"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1136-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.049940"},{"issue":"13","key":"e_1_2_9_10_1","first-page":"5289","article-title":"Role of iron in tumor cell protection from the pro\u2010apoptotic effect of nitric oxide","volume":"61","author":"Feger F.","year":"2001","journal-title":"Cancer Research"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00251-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1910"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.07.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901906"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00179-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1730"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510340230"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07414"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00728-5"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240143"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25487"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.2013-0006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/364626a0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i48.18354"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.07.013"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-009-9187-x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100667108"},{"issue":"7","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1016\/S0021-9258(20)64313-7","article-title":"Peroxynitrite oxidation of sulfhydryls: The cytotoxic potential of superoxide and nitric oxide","volume":"266","author":"Radi R.","year":"1991","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(03)00365-5"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327116665675"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12083"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708578114"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2018.06.003"},{"issue":"4","key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"e0196411","DOI":"10.1371\/journal.pone.0196411","article-title":"Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus baill","volume":"13","author":"Somit D.","year":"2018","journal-title":"PLoS One"},{"issue":"11","key":"e_1_2_9_35_1","first-page":"1157","article-title":"Inhibitors of inducible nitric oxide (NO) synthase are more effective than an NO donor in reducing carbon\u2010tetrachloride induced acute liver injury","volume":"21","author":"Tipoe G. L.","year":"2006","journal-title":"Histology and Histopathology"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.08.039"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02262.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122494"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12082"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddr.21653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.21653","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T21:15:57Z","timestamp":1760390157000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/ddr.21653"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21653","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"2019-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}