{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:20:23Z","timestamp":1781796023338,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some novel non\u2010ulcerogenic N\u2010substitutedphenyl\u20106\u2010oxo\u20103\u2010phenylpyridazines as COX\u20102 inhibitors have been developed (Supplementary material Appendix ). The novel aldehyde <jats:bold>3<\/jats:bold> was prepared by reacting 6\u2010phenylpyridazin\u20103(2<jats:italic>H<\/jats:italic>)\u2010one with 4\u2010fluorobenzaldehyde. The aldehyde <jats:bold>3<\/jats:bold> was reacted with different hydrazines and thiazolidin\u20104\u2010ones to obtain the novel N\u2010substitutedphenyl\u20106\u2010oxo\u20103\u2010phenylpyridazine derivatives. These were assessed for their anti\u2010inflammatory potential and gastric ulcerogenic effects. The molecular docking investigations were also undertaken. The spectroscopic data were coherent with the allocated structures of the compounds. The compounds <jats:bold>4a<\/jats:bold> (IC<jats:sub>50<\/jats:sub> =\u200917.45\u2009nm; <jats:italic>p<\/jats:italic> &lt;\u2009.05), <jats:bold>4b<\/jats:bold> (IC<jats:sub>50<\/jats:sub> =\u200917.40\u2009nm; <jats:italic>p\u2009&lt;<\/jats:italic> .05), <jats:bold>5a<\/jats:bold> (IC<jats:sub>50<\/jats:sub> =\u200916.76\u2009nm; <jats:italic>p<\/jats:italic> &lt;\u2009.05), and <jats:bold>10<\/jats:bold> (IC<jats:sub>50<\/jats:sub> =\u200917.15\u2009nm; <jats:italic>p<\/jats:italic> &lt;\u2009.05) displayed better COX\u20102 inhibitory activity than celecoxib (IC<jats:sub>50<\/jats:sub> =\u200917.79\u2009nm; <jats:italic>p<\/jats:italic> &lt;\u2009.05). These findings were consistent with the molecular docking investigations of <jats:bold>4a<\/jats:bold>, <jats:bold>4b<\/jats:bold>, <jats:bold>5a<\/jats:bold>, and <jats:bold>10<\/jats:bold>. The <jats:italic>in vivo<\/jats:italic> anti\u2010inflammatory profile of <jats:bold>4a<\/jats:bold>, <jats:bold>4b<\/jats:bold>, <jats:bold>5a<\/jats:bold>, and <jats:bold>10<\/jats:bold> was also superior to celecoxib and indomethacin. The compounds <jats:bold>4b<\/jats:bold>, <jats:bold>5a<\/jats:bold>, and <jats:bold>10<\/jats:bold> revealed no gastric ulcerogenic effects, wherein the compound <jats:bold>4a<\/jats:bold> produced almost negligible gastric ulcerogenic effects than celecoxib and indomethacin. The compounds <jats:bold>4a<\/jats:bold>, <jats:bold>4b<\/jats:bold>, <jats:bold>5a<\/jats:bold>, and <jats:bold>10<\/jats:bold> have been postulated as promising non\u2010ulcerogenic COX\u20102 inhibitors.<\/jats:p>","DOI":"10.1002\/ddr.21655","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T03:29:20Z","timestamp":1584329360000},"page":"573-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Synthesis of novel N\u2010substitutedphenyl\u20106\u2010oxo\u20103\u2010phenylpyridazine derivatives as cyclooxygenase\u20102 inhibitors"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-461X","authenticated-orcid":false,"given":"Abida","family":"Khan","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Apeejay Stya University  Sohna India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Diwan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Apeejay Stya University  Sohna India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdy K","family":"Thabet","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science, Northern Border University  Rafha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Northern Border University  Rafha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.03.036"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2013.09.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.075267"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.3.491"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MD00569A"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2014.12.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfluchem.2014.02.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.13005\/ojc\/330217"},{"issue":"1","key":"e_1_2_7_11_1","first-page":"26","article-title":"Cyclooxygenase\u20102 \u2010 an attractive target for fruitful drug design","volume":"80","author":"Fabiola G.","year":"2001","journal-title":"Current Science"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098617690485"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.04.048"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3184\/174751915X14412838239915"},{"key":"e_1_2_7_15_1","first-page":"543","article-title":"Antiinflammatory activity of some new 3\u2010(2H\u20101\u2010benzopyran\u20102\u2010one\u20103\u2010yl)\u20105\u2010substituted aryl isoxazolines","volume":"16","author":"Imran M.","year":"2004","journal-title":"Asian Journal of Chemistry"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2019.104259"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.02.042"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2014_1825"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1872213X11307020004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.05.069"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030685"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb1196-927"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.10.051"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E543"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1914-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X16014230"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22111864"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.44.373"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-012-1205-5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1341108"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557518666180330112416"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24183404"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2016-0194"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557515666160509125702"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-018-0739-1"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-111-27849"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddr.21655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.21655","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T21:16:07Z","timestamp":1760390167000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/ddr.21655"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21655","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"2019-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}