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Therapeutics that may assist to contain its rapid spread and reduce its high mortality rates are urgently needed. Developing vaccines against the SARS\u2010CoV\u20102 virus may take many months. Moreover, vaccines based on viral\u2010encoded peptides may not be effective against future coronavirus epidemics, as virus mutations could make them futile. Indeed, new Influenza virus strains emerge every year, requiring new immunizations. A tentative suggestion based on existing therapeutics, which would likely be resistant to new coronavirus mutations, is to use available angiotensin receptor 1 (AT1R) blockers, such as losartan, as therapeutics for reducing the aggressiveness and mortality from SARS\u2010CoV\u20102 virus infections. This idea is based on observations that the angiotensin\u2010converting enzyme 2 (ACE2) very likely serves as the binding site for SARS\u2010CoV\u20102, the strain implicated in the current COVID\u201019 epidemic, similarly to strain SARS\u2010CoV implicated in the 2002\u20132003 SARS epidemic. This commentary elaborates on the idea of considering AT1R blockers as tentative treatment for SARS\u2010CoV\u20102 infections, and proposes a research direction based on datamining of clinical patient records for assessing its feasibility.<\/jats:p>","DOI":"10.1002\/ddr.21656","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T08:15:15Z","timestamp":1583309715000},"page":"537-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":572,"title":["Angiotensin receptor blockers as tentative SARS\u2010CoV\u20102 therapeutics"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-1869","authenticated-orcid":false,"given":"David","family":"Gurwitz","sequence":"first","affiliation":[{"name":"Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.04.006"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1334554"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.02.071"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-020-01401-y"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2010.494597"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.81"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00976-0"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2020.01047"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu086"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12711"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000146120.29648.36"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03712"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000124667.34652.1a"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12573"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1267"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-020-00016-0"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02145"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-020-3192-6"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m641"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(97)82002-5"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.02.058"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6905e1"},{"key":"e_1_2_3_25_1","first-page":"m406","article-title":"Rapid response: Use of angiotensin receptor blockers such as Telmisartan, Losartsan in nCoV Wuhan Corona Virus infections\u2014Novel mode of treatment. 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