{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:14Z","timestamp":1786977494332,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007343","name":"Universit\u00e0 degli Studi di Brescia","doi-asserted-by":"publisher","award":["Project \"REFRACT\""],"award-info":[{"award-number":["Project \"REFRACT\""]}],"id":[{"id":"10.13039\/501100007343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alterations in peripheral vascular endothelial growth factor (VEGF) levels were observed in major depressive disorder and relative treatments and were shown to be influenced by genetic variants. The study objective was to explore, at a genome\u2010wide level, possible interplaying effects between the genetic background and major depressive disorder in regulating VEGF levels. Moreover, we aimed to investigate the association between these variants and response to electroconvulsive therapy. A genome\u2010wide association study was carried out both on controls and patients with major depressive disorder (\n                    <jats:italic>n<\/jats:italic>\n                    =\u2009145;\n                    <jats:italic>n<\/jats:italic>\n                    =\u2009121) in correlation with serum VEGF levels determined by ELISA. Five SNPs not included in SNP arrays were additionally genotyped. Seventy\u2010one patients with treatment\u2010resistant depression underwent electroconvulsive therapy and were evaluated as responders\/nonresponders. An association between VEGF levels and a locus in 6p21.1, downstream the\n                    <jats:italic>VEGF<\/jats:italic>\n                    gene, was evidenced both in controls (best SNP: FDR\u2010corrected\n                    <jats:italic>p<\/jats:italic>\n                    =\u20092.4\u2009\u00d7\u200910\n                    <jats:sup>\u22125<\/jats:sup>\n                    ) and in patients with major depressive disorder (best SNP: FDR\u2010corrected\n                    <jats:italic>p<\/jats:italic>\n                    =\u20092.6 \u00d7 10\n                    <jats:sup>\u20133<\/jats:sup>\n                    ). The alleles associated with lower VEGF concentrations in patients were also associated with nonresponse to electroconvulsive therapy (\n                    <jats:italic>p<\/jats:italic>\n                    =\u2009.01). These results confirm a role of SNPs in 6p21.1 locus as major influencers of circulating VEGF levels also in patients affected by major depressive disorder and indicate a possible implication in response to electroconvulsive therapy.\n                  <\/jats:p>","DOI":"10.1002\/ddr.21658","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T03:24:55Z","timestamp":1584329095000},"page":"593-599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Genetic determinants of circulating VEGF levels in major depressive disorder and electroconvulsive therapy response"],"prefix":"10.1002","volume":"81","author":[{"given":"Elisabetta","family":"Maffioletti","sequence":"first","affiliation":[{"name":"Division of Biology and Genetics, Department of Molecular and Translational Medicine University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Gennarelli","sequence":"additional","affiliation":[{"name":"Division of Biology and Genetics, Department of Molecular and Translational Medicine University of Brescia  Brescia Italy"},{"name":"Genetics Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Magri","sequence":"additional","affiliation":[{"name":"Division of Biology and Genetics, Department of Molecular and Translational Medicine University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisella","family":"Bocchio\u2010Chiavetto","sequence":"additional","affiliation":[{"name":"Genetics Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"},{"name":"Faculty of Psychology eCampus University, Novedrate  Como Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bortolomasi","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital \u201cVilla Santa Chiara\u201d  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Bonvicini","sequence":"additional","affiliation":[{"name":"Genetics Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Abate","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital \u201cVilla Santa Chiara\u201d  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Trabucchi","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital \u201cVilla Santa Chiara\u201d  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Ulivi","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS Burlo Garofolo  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9463-7808","authenticated-orcid":false,"given":"Alessandra","family":"Minelli","sequence":"additional","affiliation":[{"name":"Division of Biology and Genetics, Department of Molecular and Translational Medicine University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.146.9.1190"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.11.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2011.0289"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0000000000000133"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2006.00298.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.07.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005874"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.04.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2015.1117655"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0554"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243790"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830190015002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.04.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.09.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5103-09.2010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34506-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct075234"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12187"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.04.013"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01557.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.04.005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016982"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.02.067"},{"issue":"20","key":"e_1_2_7_26_1","first-page":"22","article-title":"The MINI\u2010international neuropsychiatric interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan D. V.","year":"1998","journal-title":"The Journal of Clinical Psychiatry"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010275"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0175-2"},{"issue":"13","key":"e_1_2_7_29_1","first-page":"23","article-title":"When at first you don't succeed: Sequential strategies for antidepressant nonresponders","volume":"58","author":"Thase M. E.","year":"1997","journal-title":"The Journal of Clinical Psychiatry"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.06.028"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.06.001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-015-9735-5"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.04.039"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddr.21658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.21658","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T21:16:08Z","timestamp":1760390168000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/ddr.21658"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21658","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"2020-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}