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Deficiency of GSH has been implicated in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder associated with loss of memory. Thus, the use of antioxidants to prevent or retard the progression of memory deteriorations in persons with AD has been the focus of intense investigations. This study was carried out to evaluate the effects of DRLC on memory and scopolamine\u2010induced amnesia, acetyl\u2010cholinesterase activity, and oxidative stress in mice. Male Swiss mice were given oral administration of saline (10 ml\/kg), DRLC (25, 50, and 100\u2009mg\/kg) or donepezil (1 mg\/kg) 30\u2009min before testing for memory performance using Y\u2010maze and object recognition models. Another set of mice were also pretreated orally with saline, DRLC (25, 50, and 100\u2009mg\/kg) or donepezil (1 mg\/kg) but in combination with scopolamine (3 mg\/kg, i.p.) daily for 7\u2009days. Thirty minutes after treatment on Day 7, memory function was then evaluated. The brain levels of acetyl\u2010cholinesterase and oxidative stress parameters were assayed. DRLC significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) enhanced memory performance and attenuated scopolamine\u2010induced amnesia. Increased acetyl\u2010cholinesterase activity and oxidative stress, as shown by decreased antioxidant substrates (glutathione and catalase) and elevated malondialdehyde contents in mice with scopolamine amnesia were also attenuated by DRLC. Our findings suggest that inhibition of oxidative stress and acetyl\u2010cholinesterase activity might contribute to the potential benefit of DRLC in persons with amnesia.<\/jats:p>","DOI":"10.1002\/ddr.21663","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T04:45:51Z","timestamp":1585284351000},"page":"620-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["D<scp>\u2010ribose\u2010L<\/scp>\u2010cysteine enhances memory task, attenuates oxidative stress and acetyl\u2010cholinesterase activity in scopolamine amnesic mice"],"prefix":"10.1002","volume":"81","author":[{"given":"Osagie","family":"Emokpae","sequence":"first","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3569-3575","authenticated-orcid":false,"given":"Benneth","family":"Ben\u2010Azu","sequence":"additional","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan  Ibadan Nigeria"},{"name":"Department of Pharmacology, Faculty of Basic Medical Sciences PAMO University of Medical Sciences  Port Harcourt, River States Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-0421","authenticated-orcid":false,"given":"Abayomi M.","family":"Ajayi","sequence":"additional","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-5111","authenticated-orcid":false,"given":"Solomon","family":"Umukoro","sequence":"additional","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2008.09.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1995.0001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3728-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.06.044"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2006.01.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.11.026"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1998.00393.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.04.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2003.09.014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-019-01805-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20170023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum protein by means of biuretreaction","volume":"177","author":"Gornall A. 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