{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:52:34Z","timestamp":1792464754553,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Paraoxonase\u20101 (PON1) has essential roles such as protecting low\u2010density lipoprotein against detoxification and oxidation of highly toxic compounds. Quinones are a class of compounds and a type of plant\u2010derived secondary metabolites. Here, PON1 was purified using very simple methods and evaluation of the interactions between the enzyme and some quinones. It was found that these quinones displayed effective inhibitor properties for PON1 with the IC\n                    <jats:sub>50<\/jats:sub>\n                    values in the range of 3.27\u201382.90\u2009\u03bcM and the\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>i<\/jats:italic>\n                    <\/jats:sub>\n                    values in the range of 2.50\u2009\u00b1\u20090.65 to 30.90\u2009\u00b1\u20097.20\u2009\u03bcM. These quinones displayed distinct inhibition mechanisms. It was determined that except for 5\u2010hydroxy\u20102\u2010methyl\u20101,4\u2010naphthoquinone and 2\u2010methyl\u20101,4\u2010naphthoquinone all quinones exhibit competitive inhibition effects. Also, molecular docking and in silico ADME studies were performed. Usage of drugs including quinone derivatives in structure with biological activity would be hazardous in some cases.\n                  <\/jats:p>","DOI":"10.1002\/ddr.21667","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T08:14:36Z","timestamp":1585642476000},"page":"628-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Naphthoquinones, benzoquinones, and anthraquinones: Molecular docking,\n                    <scp>ADME<\/scp>\n                    and inhibition studies on human serum paraoxonase\u20101 associated with cardiovascular diseases"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-1098","authenticated-orcid":false,"given":"Yeliz","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, Nihat Delibalta G\u00f6le Vocational High School Ardahan University  Ardahan Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2019.11.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0596-7288"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.06.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2018.1561458"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.06.017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2018.1470646"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341209787314936"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21889"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1620266"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12720"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22381"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2019.108605"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929866526666190301115122"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955710791330909"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17997"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13144"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2019.108608"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-1501-51"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-018-0116-1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1781"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21935"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2019.02.012"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2019.103195"},{"key":"e_1_2_6_27_1","first-page":"20","article-title":"Molecular 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