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Hence, the present research work aimed to formulate, optimize, and evaluate the in situ gel for ophthalmic drug delivery. The prepared in situ gel formulations were evaluated for clarity, pH, gelling capacity, viscosity, osmolality, in vitro release study, and kinetic evaluation. ex vivo corneal permeation\/penetration study using goat and in vivo studies on rabbits were also performed. Fourier\u2010transformed infrared spectroscopy was also applied to study possible interactions between drug and polymers. The formulations found to be stable, nonirritant, and showed sustained release of the drug for a period of up to 24\u2009hr with no ocular damage. The developed in situ gels loaded with tetrahydrozoline are alternative and promising ocular candidates for the treatment of allergic conjunctivitis.<\/jats:p>","DOI":"10.1002\/ddr.21677","type":"journal-article","created":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T10:44:28Z","timestamp":1588416268000},"page":"716-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["In vitro\u2013in vivo evaluation of tetrahydrozoline\u2010loaded ocular in situ gels on rabbits for allergic conjunctivitis management"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-3747","authenticated-orcid":false,"given":"Neslihan \u00dcst\u00fcnda\u011f","family":"Okur","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vildan","family":"Yozgatli","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy Ege University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Evren","family":"Okur","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy University of Health Sciences  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.04.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/40.8.429"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2011.11.001"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Comparative review on conventional and advanced ocular drug delivery formulations","volume":"2","author":"Arul Kumaran K. 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