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However, its role in the formalin\u2010induced nociception remains unknown. The purpose of this study was to investigate the antinociceptive effect of CFX in the 1% formalin test in rats. Formalin induced a typical nociceptive response (flinching behavior) of two phases. Local peripheral pretreatment (20\u2009min) with CFX (400\u2013800\u2009\u03bcg\/paw) slightly attenuated the flinching behavior in phase 2, but not phase 1. Acute intraperitoneal pretreatment (20\u2009min) also reduced phase 2 of the formalin test. In both cases, CFX induced a dose\u2010dependent antinociception. We also tested the effect of CFX 1\u2009day after its administration and in two schedules of repeated administration. One\u2010day pretreatment with CFX (50\u2013400\u2009mg\/kg, ip) induced a dose\u2010dependent antinociceptive effect in formalin\u2010treated rats. Repeated administration (daily during 3 or 7\u2009days) with CFX (50\u2013400\u2009mg\/kg, ip) diminished formalin\u2010induced nociception. 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