{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:04:16Z","timestamp":1760486656287,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008899","name":"University of South Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Current therapeutic drugs for Alzheimer's disease (AD) can only offer limited symptomatic benefits and do not halt disease progression. Multitargeted directed ligands (MTDLs) have been considered to be a feasible way to treat AD due to the multiple neuropathological processes in AD. Previous studies proposed that compounds containing two aromatic groups connected by a carbon chain should act as effective amyloid \u03b2 (A\u03b2) aggregation inhibitors although the optimal length of the carbon chain has not been explored. In the current study, a series of naphthalimide analogs were designed and synthesized based on the proposed structure and multiple bioactivities beneficial to the AD treatment were reported. <jats:italic>In vitro<\/jats:italic> studies showed that compound 8, which has two aromatic groups connected by a two\u2010carbon chain, exhibited significant inhibition of A\u03b2 aggregation through the prevention of elongation and association of A\u03b2 fibril growth. Furthermore, this compound also displayed antioxidative activities and neuroprotection from A\u03b2 monomer induced toxicity in primary cortical neurons. The results of the present study highlight a novel naphthalimide\u2010based compound 8 as a promising MTDL against AD. Its structural elements can be further explored for enhanced therapeutic capabilities.<\/jats:p>","DOI":"10.1002\/ddr.21708","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T02:36:21Z","timestamp":1592361381000},"page":"671-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Discovery and Characterization of Novel Naphthalimide Analogs as Potent Multitargeted Directed Ligands against Alzheimer's Disease"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5951-1399","authenticated-orcid":false,"given":"Jie","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Clinical and Diagnostic Science University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Discovery and Biomedical 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