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The high pulmonary tropism and contagiousness of the virus, severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), have stimulated new approaches to combat its widespread diffusion. In developing new pharmacological strategies, the chemical characteristic of volatility can add therapeutic value to the hypothetical drug candidate. Volatile molecules are characterized by a high vapor pressure and are consequently easily exhaled by the lungs after ingestion. This feature could be exploited from a pharmacological point of view, reaching the site of action in an uncommon way but allowing for drug delivery. In this way, a hypothetical molecule for COVID\u201019 should have a balance between its lung exhalation characteristics and both antiviral and anti\u2010inflammatory pharmacological action. Here, the feasibility, advantages, and disadvantages of a therapy based on oral administration of possible volatile drugs for COVID\u201019 will be discussed. Both aerosolized antiviral therapy and oral intake of volatile molecules are briefly reviewed, and an evaluation of 1,8\u2010cineole is provided in view of a possible clinical use and also for asymptomatic COVID\u201019.<\/jats:p>","DOI":"10.1002\/ddr.21716","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T23:19:35Z","timestamp":1595200775000},"page":"950-968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Volatile molecules for <scp>COVID<\/scp>\u201019: A possible pharmacological strategy?"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-2486","authenticated-orcid":false,"given":"Cristiano","family":"Colalto","sequence":"first","affiliation":[{"name":"Working Group \u201cPharmacognosy, Phytotherapy and Nutraceuticals\u201d Italian Pharmacological Society  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Ansa. 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