{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:50:50Z","timestamp":1783831850794,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malaria is a communicable disease which is caused by protozoan's mainly Plasmodium species (<jats:italic>P. falciparum<\/jats:italic>, <jats:italic>P. ovale<\/jats:italic>, <jats:italic>P. vivax<\/jats:italic>, <jats:italic>P. malariae and P. knowlesi<\/jats:italic>). The increasing resistance of <jats:italic>Plasmodium<\/jats:italic> to available malarial drugs poses a great responsibility for the researchers in the field of malaria. To overcome this problem of resistance, this study aimed to design and synthesize a new class of antimalarial agent with chalcone as the main moiety. Chalcones, a member of flavanoid family, consist of two aromatic rings of 1,3\u2010diphenyl\u20102\u2010propen\u20101\u2010one linked by a three carbon \u03b1,\u03b2\u2010unsaturated carbonyl system. Five derivatives were designed and among them one was selected. The CC2 was then synthesized by esterification of Para amino acetophenone followed by treatment with hydrazide to form 2\u2010(4 acetylphenoxy)acetohydrazide. This was then coupled with 2\u2010Bromo substituted Diazotized esterified anilines, which was finally linked with substituted benzaldehyde to yield CC2. These were then structurally verified by Infra Red (IR) and Nuclear Magnetic Resonance (NMR) spectroscopy. The chalcone was then tested for in vitro growth inhibition assays using SYBR GREEN\u20101 Based assay and IC<jats:sub>50<\/jats:sub> values were identified. The compound CC2 showed quite promising antimalarial activity by inhibiting cysteine protease enzyme. The acute toxicity studies of the compound were carried out as per OECD guideline 425 and the results showed no toxic signs and symptoms indicating CC2 as a safe and less toxic compound.<\/jats:p>","DOI":"10.1002\/ddr.21727","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T23:09:56Z","timestamp":1596755396000},"page":"1048-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Design, synthesis and biological evaluation of several aromatic substituted chalcones as antimalarial agents"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-3722","authenticated-orcid":false,"given":"Adarsh","family":"Gopinathan","sequence":"first","affiliation":[{"name":"Department of Pharmacy Government Medical College  Kannur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahreen","family":"Moidu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Government Medical College  Kannur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minil","family":"Mukundan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Government Medical College  Kannur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siju","family":"Ellickal Narayanan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Government Medical College  Kannur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hariraj","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Government Medical College  Kannur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Adhikari","sequence":"additional","affiliation":[{"name":"CSIR Centre for Cellular and Molecular Biology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1571","article-title":"The biology and control of malaria vectors in India","volume":"92","author":"Dash A. P.","year":"2007","journal-title":"Current Science"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01555a044"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-1011-x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","unstructured":"Dhiman S. Veer V. &Dev V.(2018).Declining transmission of malaria in India: Accelerating towards elimination. Towards malaria elimination \u2010 A leap forward. Intecopen.","DOI":"10.5772\/intechopen.77046"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20163"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11693-015-9170-1"},{"issue":"1","key":"e_1_2_6_8_1","first-page":"66","article-title":"Synthesis and biological evaluation of (7\u2010hydroxy\u20102\u2010oxo\u20102h\u2010chromen\u20104\u2010yl) acetic acidhydrazide derivatives used as a potentbiological agents","volume":"4","author":"Kardile D. P.","year":"2011","journal-title":"Rasayan Journal of Chemistry"},{"key":"e_1_2_6_9_1","unstructured":"OECD Guidelines for TestingOECD guidelines for testing of chemicals 425 acute oral toxicity \u2010 up and down procedure. Adopte: Oct 3 2008."},{"key":"e_1_2_6_10_1","unstructured":"Organic Chemistry Portal https:\/\/www.organic-chemistry.org\/namedreactions\/diazotisation.shtm."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073530"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.03.021"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.10.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34622-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2017.07.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2009.47.2.93"},{"issue":"2","key":"e_1_2_6_17_1","first-page":"47","article-title":"Synthesis and Antiplasmodial activity of some novel Chalcone derivatives","volume":"8","author":"Tomar N.","year":"2015","journal-title":"Asian Journal of Pharmaceutical and Clinical Research"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.30875\/7e6f8c91-en"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddr.21727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.21727","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T19:21:48Z","timestamp":1760469708000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/ddr.21727"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21727","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]},"assertion":[{"value":"2020-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}