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Most current investigations focused on SARS\u2010COV\u20102\u2010related effects on the renin\u2013angiotensin system and especially the resultant increase in angiotensin II, neglecting its effects on the kinin\u2013kallikrein system. SARS\u2010COV\u20102\u2010induced ACE2 inhibition leads to the augmentation of bradykinin 1\u2010receptor effects, as ACE2 inactivates des\u2010Arg9\u2010bradykinin, a bradykinin metabolite. SARS\u2010COV\u20102 also decreases bradykinin 2\u2010receptor effects as it affects bradykinin synthesis by inhibiting cathepsin L, a kininogenase present at the site of infection and involved in bradykinin production. The physiologies of both the renin\u2013angiotensin and kinin\u2013kallikrein system are functionally related suggesting that any intervention aiming to treat SARS\u2010COV\u20102\u2010infected patients by triggering one system but ignoring the other may not be adequately effective. Interestingly, the snake\u2010derived bradykinin\u2010potentiating peptide (BPP\u201010c) acts on both systems. BPP\u201010c strongly decreases angiotensin II by inhibiting ACE, increasing bradykinin\u2010related effects on the bradykinin 2\u2010receptor and increasing nitric oxide\u2010mediated effects. Based on a narrative review of the literature, we suggest that BPP\u201010c could be an optimally effective option to consider when aiming at developing an anti\u2010SARS\u2010COV\u20102 drug.<\/jats:p>","DOI":"10.1002\/ddr.21732","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T02:56:26Z","timestamp":1596682586000},"page":"38-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Snake venom\u2010derived bradykinin\u2010potentiating peptides: A promising therapy for <scp>COVID<\/scp>\u201019?"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2470-0792","authenticated-orcid":false,"given":"Ahmed S.","family":"Gouda","sequence":"first","affiliation":[{"name":"National Egyptian Center for Toxicological Researches, Faculty of Medicine University of Cairo  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-2764","authenticated-orcid":false,"given":"Bruno","family":"M\u00e9garbane","sequence":"additional","affiliation":[{"name":"Department of Medical and Toxicological Critical Care, Lariboisi\u00e8re Hospital University of Paris, INSERM UMRS\u20101144  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0901-1003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104736"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104808"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.10.010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2020.03008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.09.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211797416002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-019-00150-w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10623329709044160"},{"key":"e_1_2_11_11_1","volume-title":"Medical biochemistry","author":"Baynes J. 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