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Its structure is similar to that of SAA, but the 3\u2032,4\u2032\u2010dihydroxy\u2010<jats:italic>trans<\/jats:italic>\u2010stilbene group and the ester structure in SAA were replaced by the RES structure and an amine group, respectively. E\u2010DRS scavenged free oxygen radicals effectively, including superoxide anion (ascorbic acid &gt; E\u2010DRS\u2009&gt;\u2009SAA \u2265 rutin &gt; RES) and DPPH radical (rutin &gt; E\u2010DRS \u2265 ascorbic acid &gt; SAA\u2009&gt;\u2009RES), and exhibited powerful total antioxidant capacity (ascorbic acid &gt; E\u2010DRS\u2009&gt;\u2009SAA \u2265 rutin &gt; RES) in vitro. Furthermore, oral administration of E\u2010DRS dose\u2010dependently and significantly decreased CCl<jats:sub>4<\/jats:sub>\u2010induced oxidative stress in mice as indicated by the decreased content of hepatic malondialdehyde (MDA). In addition, oral administration of E\u2010DRS also increased the content of nonenzymatic antioxidant glutathione (GSH) and the activity of antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD) in the liver of mice. All these results demonstrated that E\u2010DRS had good antioxidant activities both in vitro and in vivo, and could be a potential antioxidant agent after further optimization and evaluation.<\/jats:p>","DOI":"10.1002\/ddr.21734","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T22:50:26Z","timestamp":1597186226000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo"],"prefix":"10.1002","volume":"82","author":[{"given":"Jin\u2010Mei","family":"Qiu","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumour Microenvironment Responsive Drug Research University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Feng","family":"Qin","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumour Microenvironment Responsive Drug Research University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen\u2010Gen","family":"Wu","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumour Microenvironment Responsive Drug Research University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong\u2010Ying","family":"Ji","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumour Microenvironment Responsive Drug Research University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Tao","family":"Tang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumour Microenvironment Responsive Drug Research University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yong","family":"Lei","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumour Microenvironment Responsive Drug Research University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumour Microenvironment Responsive Drug Research University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-0379","authenticated-orcid":false,"given":"Zhi\u2010Zhong","family":"Xie","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumour Microenvironment Responsive Drug Research University of South China  Hengyang China"},{"name":"Hunan Provincial Cooperative Innovation Centre for Molecular Target New Drug Study University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","first-page":"1","article-title":"Antiplatelet activity of synthetic and natural resveratrol in red wine","volume":"17","author":"Bertelli A. 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