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Hence, the rationally designed drugs for mitigating over\u2010activity of COX\u20102 isoenzyme play a regulatory role toward the alleviation of the progression of these disorders. However, a selective COX\u20102 inhibition chemotherapy prompts several side effects that necessitate the identification of novel molecular scaffolds for deliberating state\u2010of\u2010the\u2010art drug designing strategies. The heterocyclic \u201cazole\u201d scaffold, being polar and hydrophilic, possesses remarkable physicochemical advantages for designing physiologically active molecules capable of interacting with a wide range of biological components, including enzymes, peptides, and metabolites. The substituted derivatives of azole nuclei enable a comprehensive SAR analysis for the appraisal of bioactive profile of the deliberated molecules for obtaining the rationally designed compounds with prominent activities. The comprehensive SAR analysis readily prompted the identification of Y\u2010shaped molecules and the eminence of bulkier group for COX\u20102 selective inhibition. This review presents an epigrammatic collation of the pharmacophore\u2010profile of the chemotherapeutics based on azole motif for a selective targeting of the COX\u20102 isoenzyme.<\/jats:p>","DOI":"10.1002\/ddr.21753","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T12:35:55Z","timestamp":1604320555000},"page":"167-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["\u201cAzole\u201d as privileged heterocycle for targeting the inducible <i>cyclooxygenase<\/i> enzyme"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-9424","authenticated-orcid":false,"given":"Parteek","family":"Prasher","sequence":"first","affiliation":[{"name":"UGC Sponsored Centre for Advanced Studies, Department of Chemistry Guru Nanak Dev University  Amritsar India"},{"name":"Department of Chemistry University of Petroleum &amp; Energy Studies, Energy Acres  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