{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:31:07Z","timestamp":1772526667765,"version":"3.50.1"},"reference-count":73,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metal\u2013Organic Frameworks (MOFs) are a new class of crystalline porous structures which can be used as a novel structure in diverse fields of medical science. Several studies have shown that chromium supplementation can be effective in amelioration of biochemical parameters of diabetes and its renal complications. Therefore, a chromium\u2010containing MOF (DIFc) was synthetized by nanochelating technology in the present study and then its effect on biochemical indices in diabetic rats was evaluated. Diabetes was induced by high\u2010fat diet consumption and streptozotocin (35\u2009mg\/kg) injection and then the treatment started 8\u2009weeks after disease induction and continued for 8\u2009weeks. The results showed that DIFc treatment decreased HOMA\u2010IR index, blood urea nitrogen, uric acid and malondialdehyde in plasma samples. This nano MOF also reduced albumin, malondialdehyde and 8\u2010isoprostane in urine specimen, while it increased creatinine clearance. In conclusion, DIFc MOF demonstrated promising results in the present study, indicating that it can be developed and evaluated in future investigations with the aim of designing a novel agent for management of diabetes and its renal complications.<\/jats:p>","DOI":"10.1002\/ddr.21759","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T03:50:39Z","timestamp":1606189839000},"page":"393-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ameliorative effect of a nano chromium metal\u2013organic framework on experimental diabetic chronic kidney disease"],"prefix":"10.1002","volume":"82","author":[{"given":"Saideh","family":"Fakharzadeh","sequence":"first","affiliation":[{"name":"Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Research and Development Sodour Ahrar Shargh Company  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Kalanaky","sequence":"additional","affiliation":[{"name":"Department of Research and Development Sodour Ahrar Shargh Company  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Argani","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Dadashzadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and nanotechnology School of Pharmacy, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyman Mohammadi","family":"Torbati","sequence":"additional","affiliation":[{"name":"Department of Pathology Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9413-2295","authenticated-orcid":false,"given":"Mohammad Hassan","family":"Nazaran","sequence":"additional","affiliation":[{"name":"Department of Research and Development Sodour Ahrar Shargh Company  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Basiri","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Research Center, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"318","article-title":"Diabetic nephropathy. Mechanisms of mesangial matrix expansion","volume":"162","author":"Abrass C. K.","year":"1995","journal-title":"Western Journal of Medicine"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"34","article-title":"Chromium Picolinate for the prevention of type 2 diabetes","volume":"3","author":"Ali A.","year":"2011","journal-title":"Treatment Strategies. Diabetes"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000169"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2015.03.013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2006.8.677"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201500802"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0255"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.53322"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TA03595H"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuw011"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v1.i2.48"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2009.04.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S196050"},{"key":"e_1_2_9_15_1","first-page":"3841","article-title":"The therapeutic effects of MSc1 nanocomplex, synthesized by nanochelating technology, on experimental autoimmune encephalomyelitic C57\/BL6 mice","volume":"9","author":"Fakharzadeh S.","year":"2014","journal-title":"International Journal of Nanomedicine"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00213-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125952"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.10.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223545"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1878-5085-3-11"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0484-0"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213319"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-101835"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2608"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10470-z"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.11.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700438"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2019-0113"},{"issue":"3","key":"e_1_2_9_29_1","first-page":"198","article-title":"Increased oxidative stress in diabetic nephropathy and its relationship with soluble Klotho levels","volume":"20","author":"Inci A.","year":"2016","journal-title":"Hippokratia"},{"issue":"3","key":"e_1_2_9_30_1","article-title":"Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: Oxidative stress in diabetes, atherosclerosis, and chronic inflammation","volume":"8","author":"Ito F.","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.05.019"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.8b01055"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-015-1932-8"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i6.850"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.10.011"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-017-0496-0"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i2.160"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801715"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.5604\/1232-1966.1108599"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-014-1069-x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.15171\/jrip.2017.30"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.10058"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00313.2016"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31857-0"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.05.004"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.072"},{"key":"e_1_2_9_47_1","volume-title":"Guidance document on acute oral toxicity testing","author":"ORGANISATION FOR ECONOMIC CO\u2010OPERATION AND DEVELOPMENT. OECD Environment","year":"2001"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.851"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02592560"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10030398"},{"issue":"11","key":"e_1_2_9_51_1","first-page":"OC05","article-title":"Serum chromium levels in type 2 diabetic patients and its association with Glycaemic control","volume":"9","author":"Rajendran K.","year":"2015","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR03612A"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-1014-2"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.04.021"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-012-9475-9"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.20960\/nh.27"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0961-8"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000382028"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-9-30"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2011.03.003"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005121288"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-008-8207-7"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar990073r"},{"issue":"3","key":"e_1_2_9_64_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1753-4887.2000.tb01841.x","article-title":"Quest for the molecular mechanism of chromium action and its relationship to diabetes","volume":"58","author":"Vincent J. B.","year":"2000","journal-title":"Nutrition Reviews"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0684-5"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604872"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b01850"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1191\/0960327104ht507oa"},{"issue":"2","key":"e_1_2_9_69_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3831\/KPI.2019.22.014","article-title":"Liver dysfunction and oxidative stress in Streptozotocin\u2010induced diabetic rats: Protective role of Artemisia Turanica","volume":"22","author":"Yazdi H. B.","year":"2019","journal-title":"Journal of Pharmacopuncture"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-14"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.8b03683"},{"issue":"118805","key":"e_1_2_9_72_1","article-title":"Engineering a homogeneous alloy\u2010oxide interface derived from metal\u2010organic frameworks for selective oxidation of 5\u2010hydroxymethylfurfural to 2,5\u2010furandicarboxylic acid","volume":"270","author":"Yu\u2010TeLiao N.","year":"2020","journal-title":"Applied Catalysis B: Environmental"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-017-1360-9"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.151"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ddr.21759","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T21:33:31Z","timestamp":1760391211000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/ddr.21759"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21759","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,24]]},"assertion":[{"value":"2020-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}