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The emergence of the drug resistance and the complex interplay between these pathways further potentiates cancer related complexities. Barbiturates and their derivatives present a commendable anticancer profile by attenuating the cancer manifesting metabolic and enzymatic pathways including, but not limited to matrix metalloproteinases, xanthine oxidase, amino peptidases, histone deacetylases, and Ras\/mitogen\u2010activated protein kinase. The derivatization and conjugation of barbiturates with pharmacophores delivers a suitable hybrid profile in containing the anomalous expression of these pathways. The present report presents a succinct collation of the barbiturates and their derivatives in managing the various cancer causing pathways.<\/jats:p>","DOI":"10.1002\/ddr.21761","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T02:58:02Z","timestamp":1605754682000},"page":"364-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Barbiturate derivatives for managing multifaceted oncogenic pathways: A mini review"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-9424","authenticated-orcid":false,"given":"Parteek","family":"Prasher","sequence":"first","affiliation":[{"name":"UGC Sponsored Centre for Advanced Studies, Department of Chemistry Guru Nanak Dev University  Amritsar India"},{"name":"Department of Chemistry University of Petroleum &amp; Energy Studies  Dehradun India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-5054","authenticated-orcid":false,"given":"Mousmee","family":"Sharma","sequence":"additional","affiliation":[{"name":"UGC Sponsored Centre for Advanced Studies, Department of Chemistry Guru Nanak Dev University  Amritsar India"},{"name":"Department of Chemistry Uttaranchal University  Dehradun India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samarth P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Petroleum &amp; 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