{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:08:06Z","timestamp":1792699686954,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic foot ulcer (DFU) is an invariably common complication of diabetes, characterized by delayed wound healing process and increased inflammation. Evidence has indicated that paeoniflorin exerts an anti\u2010inflammatory effect in diabetic retinopathy. The current work was aimed to investigate the effect of paeoniflorin on inflammation and wound healing in DFU. DFU rat models by streptozotocin and skin biopsy punch, as well as high glucose\u2010treated human immortalized keratinocytes (HaCaT) were established. Levels of blood glucose, wound contraction and proinflammatory cytokine were detected after paeoniflorin administration. Several essential targets associated with the NF\u2010\u03baB and Nod\u2010like receptor protein\u20103 (NLRP3) signaling pathways were examined. Results showed markedly down\u2010regulation of interleukin (IL)\u20101\u03b2, IL\u201018 and tumor necrosis factor\u2010alpha in paeoniflorin\u2010treated DFU rats. Paeoniflorin decreased the expression levels of chemokine receptor CXCR2, nuclear NF\u2010\u03baB and p\u2010I\u03baB (Ser36), as well as increased I\u03baB level. Histological analysis and immunostaining showed lower inflammatory cells with decreased NLRP3 and cleaved caspase\u20101 levels following paeoniflorin treatment. Further in vitro evidence confirmed that paeoniflorin efficiently inhibited NLRP3 and NF\u2010\u03baB\u2010mediated inflammation in DFU by inhibiting CXCR2. These findings are suggestive of greatly attenuated wound inflammation and better wound healing in paeoniflorin\u2010treated DFU rats. Our study demonstrates that paeoniflorin is a potential therapeutic agent for DFU.<\/jats:p>","DOI":"10.1002\/ddr.21763","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T01:36:43Z","timestamp":1606268203000},"page":"404-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Paeoniflorin inhibited nod\u2010like receptor protein\u20103 inflammasome and <scp>NF\u2010\u03baB<\/scp>\u2010mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor <scp>CXCR2<\/scp>"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-4962","authenticated-orcid":false,"given":"Xiaolong","family":"Sun","sequence":"first","affiliation":[{"name":"The Second Department of Surgery, First Affiliated Hospital Heilongjiang University of Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Department of Surgery, First Affiliated Hospital Heilongjiang University of Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Department of Surgery, First Affiliated Hospital Heilongjiang University of Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Department of Surgery, First Affiliated Hospital Heilongjiang University of Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Department of Surgery, First Affiliated Hospital Heilongjiang University of Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Peripheral Vascular Disease, First Affiliated Hospital Heilongjiang University of Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06438"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2001.00867.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700129"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.05.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00347.2013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.10.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00408-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63089"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0443"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083789"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67700-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.11.2821"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/11631850-000000000-00000"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734617737659"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.75"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1450"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0927"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.01.006"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116728"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050372"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00566"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S149504"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.6.8.4506"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13054"},{"key":"e_1_2_8_28_1","first-page":"5647219","article-title":"A Protective role of paeoniflorin in fluctuant hyperglycemia\u2010induced vascular endothelial injuries through antioxidative and anti\u2010inflammatory effects and reduction of PKCbeta1","volume":"2019","author":"Wang J. 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