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Globally, it is estimated around 2000 anthrax cases occur per year. Upon infection, the organism can cause cytolysis of macrophage and produce exotoxin capable of inducing edema and lymphatic blockage. Another challenge posed by the organism is the ability to form spores in harsh conditions. Various antibiotics have been used to fight the disease. However, like many other microbes, <jats:italic>B. anthracis<\/jats:italic> may develop resistance, thus the discovery of new therapeutics is urgently required. Antimicrobial peptides (AMPs) have been discovered since 1980s and attracted researchers in the antimicrobial field. In this review, the work and studies on the attempts to discover potent AMPs to treat anthrax together with the brief overview of the synthesis and modification pathways of several AMPs have been presented.<\/jats:p>","DOI":"10.1002\/ddr.21803","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T10:30:24Z","timestamp":1613298624000},"page":"754-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Insights into antimicrobial peptides in fighting anthrax: A review"],"prefix":"10.1002","volume":"82","author":[{"given":"Theodore Ebenezer","family":"Leonard","sequence":"first","affiliation":[{"name":"Department of Pharmacy Indonesia International Institute for Life Sciences (i3L)  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsabda","family":"Siratan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Indonesia International Institute for Life Sciences (i3L)  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonny Yulita","family":"Hartiadi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Indonesia International Institute for Life Sciences (i3L)  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-5995","authenticated-orcid":false,"given":"Audrey Amira","family":"Crystalia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Indonesia International Institute for Life Sciences (i3L)  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.12.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.12.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2001.01498.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(00)00168-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0802.01-0521"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2006.00424.x"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"9","article-title":"Cathelicidin peptide rescues G. mellonella infected with B. anthracis","volume":"9","author":"Blower R. 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