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Here, fresh mouse splenocytes were obtained and stimulated with concanavalin A (ConA, 5\u00a0\u03bcg\/ml) in vitro; and experimental autoimmune hepatitis (AIH) was induced by ConA (20\u2009mg\/kg, iv) in vivo, to clarify the protective effects of CQMUH\u2010011 against AIH and its possible mechanisms. Our results demonstrated that CQMUH\u2010011 pretreatment can dose\u2010dependently inhibit the proliferation of splenocytes in vitro. In vivo, CQMUH\u2010011 administration reduced the hepatic histopathological score and the infiltration of lymphocytes in the liver parenchyma; additionally, it downregulated the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and pro\u2010inflammatory cytokines interferon (IFN)\u2010\u03b3, tumor necrosis factor (TNF)\u2010\u03b1, and interleukin (IL)\u20106 in serum, as well as those of methane dicarboxylic aldehyde and myeloperoxidase in the liver tissues. It also down\u2010regulated the expression of p\u2010NF\u2010\u03baB and related proteins in the liver tissues. Furthermore, CQMUH\u2010011 could maintain the balance of CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>\/CD3<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup> and decrease the percentages of CD8<jats:sup>+<\/jats:sup>CD69<jats:sup>+<\/jats:sup> and CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+\/\u2010<\/jats:sup>CD69<jats:sup>+<\/jats:sup> T\u2010cells in the splenocytes of ConA\u2010challenged mice. Moreover, we found thatCD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+\/\u2212<\/jats:sup>CD69<jats:sup>+<\/jats:sup> T\u2010cells were significantly correlated with ALT levels, especially CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup>CD69<jats:sup>+<\/jats:sup> T\u2010cells. In conclusion, CQMUH\u2010011 exerts potential protective effects against ConA\u2010induced hepatitis, which may be partially attributed to its inhibition of T cells, especially the suppression of the proliferation of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup>CD69<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup>CD69<jats:sup>+<\/jats:sup> subsets in the spleen. CQMUH\u2010011 also reduced the early apoptosis of lymphocytes in the thymus.<\/jats:p>","DOI":"10.1002\/ddr.21813","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T01:58:56Z","timestamp":1616032736000},"page":"1111-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>CQMUH<\/scp>\u2010011 mitigates autoimmune hepatitis via inhibiting the function of T lymphocytes"],"prefix":"10.1002","volume":"82","author":[{"given":"Qiao","family":"Ling","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Medical University  Chongqing China"},{"name":"The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangnan","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Pharmacology Chongqing Medical University  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