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Conventional sulfathiazolium zinc\u2010<jats:italic>bis<\/jats:italic>\u20102,6\u2010pyridinedicarboxylate dianionic complexes (2:1 electrolyte) were formed when hydroxyaromatic compounds such as 1,3\u2010dihydroxybenzene or 3\u2010nitrophenol were used as guest components. Thus, with the aid of the hydroxyaromatic molecules the zinc\u2010<jats:italic>bis<\/jats:italic>\u20102,6\u2010pyridinedicarboxylate complexes were stabilized with the relatively large sized sulfathiazolium cations. It was a consequence of domain expansion by the phenolic compounds. Sandwiched aromatic guests between the 2,6\u2010pyridinedicarboxylates provided appropriate packing to accommodate the two large cations in the self\u2010assemblies, which helped to modulate the amounts of sulfathiazole in different formulations. Antibacterial activities with <jats:italic>E. coli<\/jats:italic> DH5\u03b1 have shown that the salt and the complexes have lower g\/ml antibacterial activity than the parent drug.<\/jats:p>","DOI":"10.1002\/ddr.21818","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T08:54:05Z","timestamp":1617267245000},"page":"1144-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in the proportions of an active pharmaceutical through cocrystals"],"prefix":"10.1002","volume":"82","author":[{"given":"Abhay Pratap","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Guwahati  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munendra Pal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Guwahati  Guwahati Assam India"},{"name":"Research and Development Center, Sun Pharmaceutical Industries Ltd  Gurgaon Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-7529","authenticated-orcid":false,"given":"Jubaraj B.","family":"Baruah","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Guwahati  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp060126o"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CE06095C"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.9b00296"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12039-018-1458-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg201177p"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CE00304A"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp070003j"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC03777A"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp0601345"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ce26055g"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg500502j"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg201096c"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2011.09.039"},{"key":"e_1_2_8_15_1","first-page":"483","article-title":"The design of novel metronidazole benzoate structures: Exploring stoichiometric diversity","volume":"75","author":"Oliveira Y. 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