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Most of its action is mediated by selective 5\u2010HT<jats:sub>1B\/1D<\/jats:sub> receptor agonism. Recent investigations raised the possibility of repositioning of this drug to other indications beyond migraine, as increasing evidence suggests for an anti\u2010inflammatory property of sumatriptan. We performed a literature search using PubMed, Web of Science, Scopus, and Google Scholar using \u201cinflammation AND sumatriptan\u201d or \u201cinflammation AND 5HT1B\/D\u201d as the keywords. Then, articles were screened for their relevance and those directly discussing the correlation between inflammation and sumatriptan or 5HT1B\/D were included. Total references reviewed or inclusion\/exclusion were 340 retrieved full\u2010text articles (<jats:italic>n<\/jats:italic>\u00a0=\u2009340), then based on critical assessment 66 of them were included in this systematic review. Our literature review indicates that at low doses, sumatriptan can reduce inflammatory markers (e.g., interleukin\u20101\u03b2, tumor necrosis factor\u2010\u03b1, and nuclear factor\u2010\u03baB), affects caspases and changes cells lifespan. Additionally, nitric oxide synthase and nitric oxide signaling seem to be regulated by this drug. It also inhibits the release of calcitonin gene\u2010related peptide. Sumatriptan protects against many inflammatory conditions including cardiac and mesenteric ischemia\/reperfusion, skin flap, pruritus, peripheral, and central nervous system injuries such as spinal cord injury, testicular torsion\u2010detorsion, oral mucositis, and other experimental models. Considering the safety and potency of low dose sumatriptan compared to corticosteroids and other immunosuppressive medications, it is worth to take advantage of sumatriptan in inflammatory conditions.<\/jats:p>","DOI":"10.1002\/ddr.21819","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T08:54:56Z","timestamp":1617267296000},"page":"896-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Beyond its <scp>anti\u2010migraine<\/scp> properties, sumatriptan is an <scp>anti\u2010inflammatory<\/scp> agent: A systematic review"],"prefix":"10.1002","volume":"82","author":[{"given":"Moein","family":"Ala","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Massachusetts Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razieh","family":"Mohammad Jafari","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8001-5565","authenticated-orcid":false,"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Tehran University of Medical Sciences  Tehran Iran"},{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2020.1819090"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104919"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"328","article-title":"The effect of Sumatriptan in ischemic conditions in the rat heart","volume":"15","author":"Altunkaynak\u2010\u00c7amca H. \u00d6.","year":"2018","journal-title":"Turkish Journal of Pharmaceutical Sciences"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04888-w"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.04.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00401.2016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01864.x"},{"issue":"5","key":"e_1_2_9_9_1","first-page":"563","article-title":"Sumatriptan ameliorates renal injury induced by cisplatin in mice","volume":"22","author":"Bazmandegan G.","year":"2019","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04742.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.10.004"},{"key":"e_1_2_9_12_1","volume-title":"StatPearls","author":"Brar Y.","year":"2018"},{"key":"e_1_2_9_13_1","volume-title":"StatPearls","author":"Brar Y.","year":"2020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120903465"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(10)80017-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0880475"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.03.037"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0136-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07935.x"},{"key":"e_1_2_9_20_1","first-page":"107","article-title":"Abolition of seizure provoking effect of sumatriptan by fluoxetine in pentylenetetrazol induced seizures in rats","volume":"7","author":"Chavan V. 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